P7C3 ameliorates barium chloride‐induced skeletal muscle injury activating transcriptomic and epigenetic modulation of myogenic regulatory factors
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31346
Abstract: Skeletal muscle injury affects the quality of life in many pathologies, including volumetric muscle loss, contusion injury, and aging. We hypothesized that the nicotinamide phosphoribosyltransferase (Nampt) activator P7C3 improves muscle repair following injury. In the… read more here.
Keywords: skeletal muscle; muscle injury; muscle; treated mice ... See more keywords
Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12887
Abstract: BACKGROUND Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in NAD salvage pathway is decreased in metabolic diseases, and its precise role in skeletal muscle function is not known. We tested the hypothesis, Nampt activation by P7C3… read more here.
Keywords: fold increase; muscle; p7c3; p7c3 mice ... See more keywords
Higher concentration of P7C3 than required for neuroprotection suppresses renal cell carcinoma growth and metastasis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer"
DOI: 10.7150/jca.90439
Abstract: Background: P7C3 is a novel compound that has been widely applied in neurodegenerative diseases and nerve injury repair. Here, we show that higher concentrations of P7C3 than are required for in vivo neuroprotection have the… read more here.
Keywords: rcc; cell; rrm2; p7c3 ... See more keywords