P85 regulates neuronal migration through affecting neuronal morphology during mouse corticogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell and Tissue Research"
DOI: 10.1007/s00441-017-2707-8
Abstract: In mammalian developing embryonic cortex, projection neurons migrate from the ventricular zone to the cortical plate, guided by radial glial cells with a transformation between bipolar and multipolar morphology. Previous studies have demonstrated that the… read more here.
Keywords: morphology mouse; neuronal morphology; p85; neuronal migration ... See more keywords
Micellar solubilization of Lavender oil in aqueous P85/P123 systems: Investigating the associated micellar structural transitions, therapeutic properties and existence of double cloud points
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.116643
Abstract: Abstract Importance of pluronic P85 as carrier for drugs arises due to its ability to sensitize cell membranes for delivery of drugs across multi drug resistant cancer cells and blood brain barrier. It is thus… read more here.
Keywords: structural transitions; therapeutic properties; micellar structural; p85 p123 ... See more keywords
Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29585-x
Abstract: PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110α, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report… read more here.
Keywords: domain mutant; helical domain; domain mutation; pik3ca helical ... See more keywords
Class IA PI3K regulatory subunits: p110-independent roles and structures
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190845
Abstract: The phosphatidylinositol 3-kinase (PI3K) pathway is a critical regulator of many cellular processes including cell survival, growth, proliferation and motility. Not surprisingly therefore, the PI3K pathway is one of the most frequently mutated pathways in… read more here.
Keywords: regulatory subunits; p110 independent; pi3k regulatory; class pi3k ... See more keywords
Injectable (−)-gossypol-loaded Pluronic P85 micelles for cancer chemoradiotherapy
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2016.1257833
Abstract: Abstract Purpose: The aim of tumor-specific chemoradiotherapy is to achieve synergistic anticancer effects with clinically acceptable toxicity. Our previous studies showed that Pluronic P85 augments radiation cancer cell killing of (±)-gossypol in vitro. In this… read more here.
Keywords: p85; gossypol loaded; pluronic p85; cancer ... See more keywords
PIK-24 Inhibits RSV-Induced Syncytium Formation via Direct Interaction with the p85α Subunit of PI3K
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01453-22
Abstract: PI3K protein has many functions and regulates various cellular processes. As an important regulatory subunit of PI3K, p85α can regulate the activity of PI3K signaling. ABSTRACT Phosphoinositide-3 kinase (PI3K) signaling regulates many cellular processes, including… read more here.
Keywords: pi3k; pi3k signaling; syncytium formation; p85 ... See more keywords