Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model
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DOI: 10.1042/bsr20160258
Abstract: In higher eukaryotes, cell proliferation is regulated by class I phosphatidylinositol 3-kinase (PI3K), which transduces stimuli received from neighboring receptors by local generation of PtdIns(3,4,5)P3 in cellular membranes. PI3K is a heterodimeric protein consisting of… read more here.
Keywords: p85 mutations; p110; phosphatidylinositol kinase; model ... See more keywords