Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2022.02.18.481032
Abstract: The design of a constitutively active form of the C-terminal kinase domain of the p90 ribosomal S6 kinase 2 (RSK2) is described, and this is based on a phosphomimetic mutation and a C-terminal truncation, yielding… read more here.
Keywords: p90 ribosomal; kinase domain; kinase; ribosomal kinases ... See more keywords
Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells.
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DOI: 10.3892/ol.2017.5597
Abstract: Ribosomal S6 kinases (RSKs) are directly regulated by extracellular signal-regulated kinase (ERK) signaling and are implicated in cell growth, survival, motility and senescence. The present study observed that RSK1 was overexpressed in primary untreated leukemia… read more here.
Keywords: luteolin novel; kinase; p90 ribosomal; migration ... See more keywords