Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals: Implications for Atherogenesis
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DOI: 10.1161/circulationaha.118.036232
Abstract: Background: The incidence of cardiovascular disease is higher in HIV-positive (HIV+) patients than it is in the average population, and combination antiretroviral therapy (cART) is a recognized risk factor for cardiovascular disease. However, the molecular… read more here.
Keywords: p90rsk nrf2; activity; senescent phenotype; cart ... See more keywords
Radiation therapy induces immunosenescence mediated by p90RSK
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.988713
Abstract: Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches. It is becoming… read more here.
Keywords: immunosenescence; role; expression; p90rsk ... See more keywords
p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors
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DOI: 10.3390/cancers15010121
Abstract: Simple Summary p90RSK is a downstream effector protein of the MAPK pathway. In many human cancers, the MAPK pathway is constitutively activated due to oncogenic mutations of its components. Consequently, p90RSK is hyperactive and capable… read more here.
Keywords: mdm2 phosphorylation; p53 pathway; thyroid tumors; p90rsk ... See more keywords
Role of p90RSK in Kidney and Other Diseases
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DOI: 10.3390/ijms20040972
Abstract: The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also designated as p90RSK. p90RSK plays an important role in the Ras-mitogen-activated… read more here.
Keywords: role p90rsk; kidney diseases; p90rsk plays; role ... See more keywords
Inhibition of p90RSK Ameliorates PDGF-BB-Mediated Phenotypic Change of Vascular Smooth Muscle Cell and Subsequent Hyperplasia of Neointima
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DOI: 10.3390/ijms24098094
Abstract: Platelet-derived growth factor type BB (PDGF-BB) regulates vascular smooth muscle cell (VSMC) migration and proliferation, which play critical roles in the development of vascular conditions. p90 ribosomal S6 kinase (p90RSK) can regulate various cellular processes… read more here.
Keywords: cell; inhibition; hyperplasia; p90rsk ... See more keywords
Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT
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DOI: 10.5483/bmbrep.2019.52.12.234
Abstract: Cisplatin (Cis-DDP) is one of the most widely used anti-cancer drugs. It is applicable to many types of cancer, including lung, bladder, and breast cancer. However, its use is now limited because of drug resistance.… read more here.
Keywords: cancer cells; cancer; breast cancer; p90rsk ... See more keywords