Allosteric p97 Inhibitors Can Overcome Resistance to ATP‐Competitive p97 Inhibitors for Potential Anticancer Therapy
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DOI: 10.1002/cmdc.201900722
Abstract: Abstract: A major challenge of targeted cancer therapy is the selection for drug‐resistant mutations in tumor cells leading to loss of treatment effectiveness. p97/VCP is central regulator of protein homeostasis and a promising anticancer target… read more here.
Keywords: p97 inhibitors; allosteric p97; atp competitive; competitive p97 ... See more keywords