UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30963-z
Abstract: Clearance of damaged mitochondria through mitophagy is critical for maintaining mitochondrial fidelity and the prevention of neurodegeneration. Here, we report on the UBX domain-containing, p97/VCP cofactor UBXD1/UBXN6/UBXDC2 and its role in mitophagy. Recognizing depolarized mitochondria… read more here.
Keywords: mitophagy ubxd1; mitochondrial recruitment; p97 vcp; p97 ... See more keywords
p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-A.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e23-01-0035
Abstract: The centromere is a unique chromatin domain that links sister chromatids and forms the attachment site for spindle microtubules in mitosis. Centromere inheritance is largely DNA sequence-independent but strongly reliant on a self-propagating chromatin domain… read more here.
Keywords: centromeric cenp; p97 vcp; chromatin; ccan proteins ... See more keywords