Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures.
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DOI: 10.2210/pdb6kwy/pdb
Abstract: Proteasomes are highly abundant and conserved protease complexes that eliminate unwanted proteins in the cells. As a single-chain ATP-independent nuclear proteasome activator, proteasome activator 200 (PA200) associates with 20S core particle to form proteasome complex… read more here.
Keywords: pa200 20s; proteasome; cryo structures; pa200 ... See more keywords
Proteasome activator PA200 maintains stability of histone marks during transcription and aging
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DOI: 10.7150/thno.48744
Abstract: The epigenetic inheritance relies on stability of histone marks, but various diseases, including aging-related disorders, are usually associated with alterations of histone marks. Whether and how the proteasome is responsible for maintaining the histone marks… read more here.
Keywords: marks transcription; transcription; stability histone; pa200 ... See more keywords