Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures.
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DOI: 10.2210/pdb6kwy/pdb
Abstract: Proteasomes are highly abundant and conserved protease complexes that eliminate unwanted proteins in the cells. As a single-chain ATP-independent nuclear proteasome activator, proteasome activator 200 (PA200) associates with 20S core particle to form proteasome complex… read more here.
Keywords: pa200 20s; proteasome; cryo structures; pa200 ... See more keywords
PA200-Mediated Proteasomal Protein Degradation and Regulation of Cellular Senescence
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DOI: 10.3390/ijms25115637
Abstract: Cellular senescence is closely related to DNA damage, proteasome inactivity, histone loss, epigenetic alterations, and tumorigenesis. The mammalian proteasome activator PA200 (also referred to as PSME4) or its yeast ortholog Blm10 promotes the acetylation-dependent degradation… read more here.
Keywords: senescence; cellular senescence; degradation; mediated proteasomal ... See more keywords
Proteasome activator PA200 maintains stability of histone marks during transcription and aging
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DOI: 10.7150/thno.48744
Abstract: The epigenetic inheritance relies on stability of histone marks, but various diseases, including aging-related disorders, are usually associated with alterations of histone marks. Whether and how the proteasome is responsible for maintaining the histone marks… read more here.
Keywords: marks transcription; transcription; stability histone; pa200 ... See more keywords