Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models
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DOI: 10.1371/journal.pone.0278130
Abstract: Huntington’s disease is an autosomal dominant heritable disorder caused by an expanded CAG trinucleotide repeat at the N-terminus of the Huntingtin (HTT) gene. Lowering the levels of soluble mutant HTT protein prior to aggregation through… read more here.
Keywords: pa28 activation; aggregation; reduction pa28; mutant htt ... See more keywords