Over-expressed RHEB promotes the progression of pancreatic adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119462
Abstract: AIMS Mammalian/mechanistic target of rapamycin (mTOR) is essential in the progression of pancreatic adenocarcinoma (PAAD). But the role of Ras homolog enriched in brain (RHEB), a key activator of mTORC1, is unclear in this disease.… read more here.
Keywords: paad; pancreatic adenocarcinoma; expressed rheb; rheb ... See more keywords
CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2078940
Abstract: ABSTRACT Pancreatic adenocarcinoma (PAAD) is a common digestive tract malignant tumor with an extremely poor prognosis. The survival and prognosis may significantly improve if it is diagnosed early. Therefore, identifying biomarkers for early diagnosis is… read more here.
Keywords: mitochondrial homeostasis; cdc25c; pancreatic adenocarcinoma; paad ... See more keywords
High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients
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DOI: 10.1155/2020/2585862
Abstract: TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between… read more here.
Keywords: high txlna; paad; pancreatic adenocarcinoma; txlna expression ... See more keywords
Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors
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DOI: 10.1155/2022/1129062
Abstract: Background Digestive system tumors (DSTs) have high morbidity and mortality worldwide. This study explored the potential value of ubiquitin-conjugating enzyme E2 I (UBE2I) in pan-digestive system tumors (pan-DSTs). Methods Differential expression, tumor stages, and survival… read more here.
Keywords: paad; methylation; expression; analysis ... See more keywords
A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma
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DOI: 10.1155/2022/1934381
Abstract: Pancreatic adenocarcinoma (PAAD) is a major threat to people's health. PRDM1 is a transcription factor with multiple functions, and its functions have been validated in a variety of tumors; however, there are few studies reported… read more here.
Keywords: paad; database; prognostic marker; pancreatic adenocarcinoma ... See more keywords
Identification of EMT-Related lncRNAs as Potential Prognostic Biomarkers and Therapeutic Targets for Pancreatic Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/8259951
Abstract: Epithelial-mesenchymal transition (EMT) can promote carcinoma progression by multiple mechanisms; many studies demonstrated the invasiveness of pancreatic adenocarcinoma (PAAD) associated with the EMT, but how it acts through an lncRNA-dependent manner is unknown. Here, we… read more here.
Keywords: paad; risk; emt related; pancreatic adenocarcinoma ... See more keywords
A Novel Immune-Related Prognostic Signature Predicting Survival in Patients with Pancreatic Adenocarcinoma
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DOI: 10.1155/2022/8909631
Abstract: Pancreatic adenocarcinoma (PAAD) carries the lowest survival rate of all major organ cancers, which is of dismal prognosis and high mortality rate. Thus, the present study attempted to identify a few novel prognostic biomarkers and… read more here.
Keywords: immune related; related prognostic; prognostic signature; paad ... See more keywords
Development of a Prognostic Model Based on Pyroptosis-Related Genes in Pancreatic Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/9141117
Abstract: Background The importance of pyroptosis in tumorigenesis and cancer progression is becoming increasingly apparent. However, the efficacy of using pyroptosis-related genes (PRGs) in predicting the prognosis of pancreatic adenocarcinoma (PAAD) patients is unknown. Methods This… read more here.
Keywords: paad; pyroptosis related; risk; model ... See more keywords
A Novel Cuproptosis-Associated Gene Signature to Predict Prognosis in Patients with Pancreatic Cancer
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DOI: 10.1155/2023/3419401
Abstract: Background Pancreatic cancer (PAAD) is a malignant tumor with a poor prognosis and lacks sensitive biomarkers for diagnosis and targeted therapy. Cuproptosis, a recently proposed form of cell death based on cellular copper ion concentration,… read more here.
Keywords: paad; cuproptosis; prognosis; risk model ... See more keywords
A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma
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DOI: 10.1186/s12935-022-02562-6
Abstract: Background Pancreatic adenocarcinoma (PAAD) is a severe malignant with a 5-year survival rate of approximately 9%. Oleanolic acid is a well-known natural triterpenoid which exhibits pharmacological activities. We previously synthesized a series of oleanolic acid… read more here.
Keywords: cell death; paad; cell; crisis ... See more keywords
LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis
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DOI: 10.1371/journal.pone.0245908
Abstract: This study aimed to find the prognostic value of Beta-lactamase-like (LACTB) in pancreatic adenocarcinoma (PAAD) patients. The mRNA expression of LACTB was upregulated in PAAD and was correlated with vital status (P = 0.0199). The… read more here.
Keywords: lactb mrna; paad; poor prognosis; expression ... See more keywords