Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.01.024
Abstract: Summary Reduced poly(A)-binding protein nuclear 1 (PABPN1) levels cause aging-associated muscle wasting. PABPN1 is a multifunctional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compared the transcriptome with the… read more here.
Keywords: muscle; deacetylation inhibition; muscle wasting; pabpn1 ... See more keywords
PABPN1 functions as a hub in the assembly of nuclear poly(A) domains that are essential for mouse oocyte development
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn9016
Abstract: Growing oocytes store a large amount of maternal mRNA to support the subsequent “maternal-zygotic transition” process. At present, it is not clear how the growing oocytes store and process the newly transcribed mRNA under physiological… read more here.
Keywords: hub; poly domains; nuclear poly; mouse ... See more keywords
PABPN1 prevents the nuclear export of an unspliced RNA with a constitutive transport element and controls human gene expression via intron retention.
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079294.122
Abstract: Intron retention is a type of alternative splicing where one or more introns remain unspliced in a polyadenylated transcript. Although many viral systems are known to translate proteins from mRNAs with retained introns, restriction mechanisms… read more here.
Keywords: intron; nuclear export; intron retention; pabpn1 ... See more keywords