Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism
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DOI: 10.1038/s41422-020-0280-2
Abstract: The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation… read more here.
Keywords: mechanism; ligand binding; cryo structures; receptor ... See more keywords