PACAP through EGFR transactivation preserves human corneal endothelial integrity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28293
Abstract: The corneal endothelium is composed of a single hexagonal‐shaped cells layer adherent to the Descemet's membrane. The primary function of these cells is maintaining of tissue clarity by regulating its hydration. Trauma, aging or other… read more here.
Keywords: pacap; corneal endothelial; egfr transactivation; endothelial integrity ... See more keywords
Decreased Plasma Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Levels are Linked with Disease Severity in Patients with Liver Cirrhosis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10163-6
Abstract: Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide that has been found to reduce liver inflammation and protect liver from steatosis. We aimed to measure the level of plasma PACAP in patients with liver… read more here.
Keywords: liver cirrhosis; child pugh; pacap; pacap levels ... See more keywords
Conditioned medium from adipose mesenchymal stromal cells stimulated with pituitary adenylate cyclase-activating polypeptide (PACAP) mitigates RINm5F pancreatic β-cell dysfunction
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology Reports"
DOI: 10.1007/s11033-025-10717-7
Abstract: The regenerative potential of mesenchymal stromal cells (MSCs) is linked to their secretion of bioactive molecules that modulate cellular processes. Different immunomodulatory molecules enhance their secretory and functional capacity. PACAP reduces oxidative stress and apoptosis,… read more here.
Keywords: conditioned medium; mesenchymal stromal; stromal cells; rinm5f pancreatic ... See more keywords
Examination of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Potential Biomarker in Heart Failure Patients
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-1025-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated… read more here.
Keywords: heart; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1146-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with neuroprotective and neurotrophic effects. This suggests its influence on the development of teeth, which are, similarly to the nervous system, ectoderm and neural crest derivatives. Our… read more here.
Keywords: deficient mice; pacap; pacap deficient; notch signaling ... See more keywords
More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use?
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-025-02366-z
Abstract: Discovered in 1989, pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with strong neuroprotective properties, as shown in various neurodegenerative preclinical models of Parkinson, Alzheimer, or Huntington diseases. PACAP neuroprotection has also been reported in… read more here.
Keywords: effect pacap; decades discovery; neuroprotective effect; pacap ... See more keywords
PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9727-8
Abstract: The detrimental effects of heavy drinking and smoking are multiplied when the two are combined. Treatment modalities for each and especially for the combination are very limited. Although in low concentration, alcohol and nicotine, each… read more here.
Keywords: nicotine; pacap; toxicity; drinking smoking ... See more keywords
Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9841-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a well-known neuropeptide with strong neurotrophic and neuroprotective effects. PACAP exerts its protective actions via three G protein-coupled receptors: the specific Pac1 receptor (Pac1R) and the Vpac1/Vpac2 receptors, the… read more here.
Keywords: mptp; pacap; disease; expression ... See more keywords
Pleiotropic pituitary adenylate cyclase-activating polypeptide (PACAP): Novel insights into the role of PACAP in eating and drug intake
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146626
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) was discovered thirty years ago, but its role in eating and drug use disorders has only recently begun to be investigated. The present review develops the hypothesis that, although PACAP… read more here.
Keywords: intake; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Therapeutic potential of PACAP in alcohol toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.01.017
Abstract: Alcohol addiction is a worldwide concern as its detrimental effects go far beyond the addicted individual and can affect the entire family as well as the community. Considerable effort is being expended in understanding the… read more here.
Keywords: potential pacap; pacap; alcohol toxicity; pacap alcohol ... See more keywords
Role of the PACAP system of the extended amygdala in the acoustic startle response in rats
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107761
Abstract: Anxiety-related disorders are the most prevalent mental disorders in the world and they are characterized by abnormal responses to stressors. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide highly expressed in the extended amygdala, a… read more here.
Keywords: response; pacap; role pacap; extended amygdala ... See more keywords