Targeting enkephalins and pituitary adenylate cyclase-activating polypeptide (PACAP) in migraine
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac260
Abstract: modulating PACAP-38-induced hypersensitivity between the RAMP1 deficient and wild-type mice. Furthermore, the humanized monoclonal CGRP antibody (ALD405) did not prevent PACAP-38-induced hypersensitivity in wild-type mice. In addition, the study found that the TRPA1 channel was… read more here.
Keywords: targeting enkephalins; migraine; pacap induced; pacap ... See more keywords
OMICS Analyses Unraveling Related Gene and Protein-Driven Molecular Mechanisms Underlying PACAP 38-Induced Neurite Outgrowth in PC12 Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044169
Abstract: The study aimed to understand mechanism/s of neuronal outgrowth in the rat adrenal-derived pheochromocytoma cell line (PC12) under pituitary adenylate cyclase-activating polypeptide (PACAP) treatment. Neurite projection elongation was suggested to be mediated via Pac1 receptor-mediated… read more here.
Keywords: induced neurite; pacap induced; pacap; gene protein ... See more keywords