Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: implications for drug discovery.
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DOI: 10.1111/bph.15700
Abstract: BACKGROUND AND PURPOSE The pituitary adenylate cyclase-activating peptide (PACAP) peptide family is of clinical interest for the treatment of migraine. These peptides activate three different PACAP-responsive class B G protein-coupled receptors: the PAC1 , VPAC1… read more here.
Keywords: pacap responsive; pacap; signalling profiles; pharmacology ... See more keywords
PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies
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DOI: 10.3390/ijms232213797
Abstract: Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide expressed in the trigeminal ganglia (TG). The TG conducts nociceptive signals in the head and may play roles in migraine. PACAP infusion provokes headaches in healthy individuals… read more here.
Keywords: pac1 vpac1; pacap; vpac1 vpac2; receptor expression ... See more keywords