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   Articles with "pacbio sequencing" as a keyword



Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma L5178Y cells and Caenorhabditis elegans worms by PacBio sequencing

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recommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22473

Abstract: Many conventional genetic toxicology assays require specialized cell cultures or animals and can only detect mutations that inactivate the function of a reporter gene. These limitations make such assays incompatible with many toxicological models but… read more here.

Keywords: elegans worms; pacbio sequencing; genome wide; detection ... See more keywords

Achieving Chromosome-Level Genome Assembly of Onychostoma macrolepis with PacBio Sequencing and Hi-C Technologies

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recommendations! Published in 2025 at "Scientific Data"

DOI: 10.1038/s41597-025-05610-8

Abstract: Onychostoma macrolepis is an emerging commercial fish with high edible value. Due to overfishing and environmental pollution, the wild population of Onychostoma macrolepis is declining sharply. In this study, we successfully assembled a chromosome-level genome… read more here.

Keywords: pacbio sequencing; onychostoma macrolepis; chromosome level; genome ... See more keywords

Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline

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recommendations! Published in 2018 at "Molecular Microbiology"

DOI: 10.1111/mmi.13873

Abstract: The Lyme disease spirochete evades the host immune system by combinatorial variation of VlsE, a surface antigen. Antigenic variation occurs via segmental gene conversion from contiguous silent cassettes into the vlsE locus. Because of the… read more here.

Keywords: pacbio sequencing; variation; antigenic variation; pipeline ... See more keywords

PaSS: a sequencing simulator for PacBio sequencing

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recommendations! Published in 2019 at "BMC Bioinformatics"

DOI: 10.1186/s12859-019-2901-7

Abstract: BackgroundThird-generation sequencing platforms, such as PacBio sequencing, have been developed rapidly in recent years. PacBio sequencing generates much longer reads than the second-generation sequencing (or the next generation sequencing, NGS) technologies and it has unique… read more here.

Keywords: pacbio sequencing; sequencing data; simulator; pass ... See more keywords