Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2017.04.001
Abstract: PACE4, one of the seven members of the proprotein convertase family, plays an important role in the progression of prostate cancer. Therefore, its inhibition has become an attractive target to develop new therapies against this… read more here.
Keywords: inhibitor; pace4; macrocyclization potent; inhibitor benefits ... See more keywords
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01144
Abstract: The serine protease, PACE4, is a proprotein convertase that plays a substantial role in malignancy of prostate cancer. Our initial selective PACE4 inhibitor (Ac-LLLLRVKR-NH2) has evolved to the current lead compound C23 (Ac-dLeu-LLLRVK-Amba), which is… read more here.
Keywords: pace4; antiproliferative activity; cell permeability; prostate cancer ... See more keywords