Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels
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DOI: 10.1371/journal.pcbi.1005675
Abstract: Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker cell function by activation of electrogenic Na/Ca exchanger (NCX) during diastole. Prior studies demonstrated the existence of powerful compensatory mechanisms of LCR regulation… read more here.
Keywords: transient decay; pacemaker cell; pup; calcium ... See more keywords
Local tissue mechanics control cardiac pacemaker cell embryonic patterning
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DOI: 10.26508/lsa.202201799
Abstract: Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function. Cardiac pacemaker cells (CPCs) initiate the electric impulses that drive the rhythmic beating of the heart. CPCs reside in a heterogeneous,… read more here.
Keywords: mechanics; local tissue; cardiac pacemaker; pacemaker cell ... See more keywords
The paradigm shift: Heartbeat initiation without “the pacemaker cell”
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DOI: 10.3389/fphys.2022.1090162
Abstract: The current dogma about the heartbeat origin is based on “the pacemaker cell”, a specialized cell residing in the sinoatrial node (SAN) that exhibits spontaneous diastolic depolarization triggering rhythmic action potentials (APs). Recent high-resolution imaging,… read more here.
Keywords: cell; subthreshold signals; heartbeat; pacemaker cell ... See more keywords