Prototypical pacemaker neurons interact with the resident microbiota
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1920469117
Abstract: Significance Here, we discover prototypical pacemaker neurons in the ancient cnidarian Hydra and provide evidence for a direct interaction of these neurons with the commensal microbiota. We uncover a remarkable gene-expression program conservation between the… read more here.
Keywords: pacemaker cells; pacemaker; pacemaker neurons; resident microbiota ... See more keywords
Circadian pacemaker neurons display cophasic rhythms in basal calcium level and in fast calcium fluctuations.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109969119
Abstract: SignificanceDaily rhythms in the molecular clock, in calcium, and in electrical activity all interact to support the functions of circadian pacemaker neurons. However, the regulatory mechanisms that unify these properties are not defined. Here, we… read more here.
Keywords: calcium fluctuations; pacemaker neurons; circadian pacemaker; cophasic rhythms ... See more keywords
Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons
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DOI: 10.1073/pnas.2113403119
Abstract: Significance The hierarchically organized master and slave clock neurons are widely believed to generate circadian rhythms via an identical molecular clockwork. However, their different roles in regulating those rhythms raise the question of whether their… read more here.
Keywords: rhythms; master; molecular clockworks; pacemaker neurons ... See more keywords