Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress, mitochondrial dysfunction, and activating the AMPK pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23555
Abstract: Pachymic acid has various pharmacological effects, including antiâinflammatory, antioxidant, immunomodulatory, and antitumor. However, the role of pachymic acid in cervical cancer remains unclear. So, we investigated the effects of pachymic acid in cervical cancer and… read more here.
Keywords: cervical cancer; hela cells; acid cervical; acid ... See more keywords
Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2021.1942924
Abstract: Abstract Context Pachymic acid and bavachin are commonly used drugs in the therapy of lung cancer. Objective The co-administration of pachymic acid and bavachin was investigated to evaluate their potential drug-drug interaction. Materials and methods… read more here.
Keywords: pachymic acid; study; acid bavachin; interaction ... See more keywords
Pachymic acid inhibits the tumorigenicity of gastric cancer cells by the mitochondrial pathway
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DOI: 10.1097/cad.0000000000000449
Abstract: Pachymic acid (PA), a lanostane-type triterpenoid derived from traditional Chinese herbals, has been reported to have antitumor activity in versatile cancer cells. However, the antitumor effect of PA in gastric cancer (GC) cells remains unclear.… read more here.
Keywords: pachymic acid; gastric cancer; cancer cells; cancer ... See more keywords
Pachymic Acid Inhibits the Migration and EpithelialâMesenchymal Transition of Renal Cell Carcinoma
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DOI: 10.1177/1934578x221132038
Abstract: Background: Renal cell carcinoma (RCC) is a common cancer of the urinary system. Chinese medicine is being extensively used in the treatment of various cancers. Recent studies found that Poria cocos, a widely used Chinese… read more here.
Keywords: cell carcinoma; cell; renal cell; rcc ... See more keywords
Functional Analysis of Sterol O-Acyltransferase Involved in the Biosynthetic Pathway of Pachymic Acid in Wolfiporia cocos
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DOI: 10.3390/molecules27010143
Abstract: Pachymic acid from Wolfiporia cocos possesses important medicinal values including anti-bacterial, anti-inflammatory, anti-viral, invigorating, anti-rejection, anti-tumor, and antioxidant activities. However, little is known about the biosynthetic pathway from lanostane to pachymic acid. In particular, the… read more here.
Keywords: wolfiporia cocos; pachymic acid; acid; acid wolfiporia ... See more keywords