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   Articles with "paclitaxel induced" as a keyword



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DNMT3a‐triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel‐induced neuropathic pain

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recommendations! Published in 2019 at "International Journal of Cancer"

DOI: 10.1002/ijc.32155

Abstract: Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K2p1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection… read more here.

Keywords: k2p1; paclitaxel induced; dnmt3a; drg ... See more keywords
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Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms

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recommendations! Published in 2018 at "Neurological Sciences"

DOI: 10.1007/s10072-018-3575-z

Abstract: Chemotherapeutic drugs induce various side effects including painful peripheral neuropathy that represents a major concern. The widely used anticancer drug paclitaxel causes neurological side effects such as burning pain, allodynia, and hyperalgesia. Neuroprotective substances that… read more here.

Keywords: paclitaxel induced; treatment; based treatment; allodynia hyperalgesia ... See more keywords
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DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.

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recommendations! Published in 2021 at "Neurochemical research"

DOI: 10.1007/s11064-021-03260-x

Abstract: Paclitaxel is a common chemotherapeutic agent in cancer treatment, while it often causes chemotherapy-induced peripheral neuropathy (CIPN), which manifested as hyperalgesia and allodynia, and its mechanism remains largely unknown. The previous study has shown that matrix metalloproteinase-2 (MMP-2)… read more here.

Keywords: sumoylation; paclitaxel induced; induced neuropathic; neuropathic pain ... See more keywords
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CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons

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recommendations! Published in 2020 at "Neurotherapeutics"

DOI: 10.1007/s13311-020-00931-5

Abstract: Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely unknown mechanisms that underlie CIPNP genesis.… read more here.

Keywords: dnmt3a; paclitaxel induced; drg; neurons creb ... See more keywords
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Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions

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recommendations! Published in 2019 at "Human Cell"

DOI: 10.1007/s13577-019-00238-4

Abstract: Chemotherapy-induced neuropathic pain (CINP) is a common and debilitating side effect of cancer treatment. Evodiamine, a major effective compound isolated from Evodia rutaecarpa, has been associated with anti-inflammatory and anti-nociceptive effects, an important therapeutic strategy… read more here.

Keywords: paclitaxel induced; induced neuropathic; neuropathic pain; evodiamine ... See more keywords
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TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2018.04.014

Abstract: ABSTRACT Paclitaxel is a cytotoxic drug which frequently causes sensory peripheral neuropathy in patients. Increasing evidence suggests that altered intracellular calcium (Ca2+) signals play an important role in the pathogenesis of this condition. In the… read more here.

Keywords: paclitaxel induced; trpv4 channels; neurotoxicity; ca2 ... See more keywords
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1865 Preventative and Therapeutic Effects of Low-Temperature Atmospheric-Pressure Plasma in a Mouse Model of Paclitaxel-Induced Neuropathy

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recommendations! Published in 2019 at "Journal of Minimally Invasive Gynecology"

DOI: 10.1016/j.jmig.2019.09.249

Abstract: Study Objective Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment. No medication has been shown to be effective in the treatment of CIPN. Low temperature plasma (LTP) has proven to be… read more here.

Keywords: low temperature; paclitaxel induced; induced neuropathy; treatment ... See more keywords
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Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study.

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recommendations! Published in 2021 at "Journal of pharmacological sciences"

DOI: 10.1016/j.jphs.2021.03.001

Abstract: We performed clinical retrospective study in female cancer patients and fundamental experiments in mice, in order to clarify risk factors for paclitaxel-induced peripheral neuropathy (PIPN). In the clinical study, 131 of 189 female outpatients with… read more here.

Keywords: paclitaxel induced; peripheral neuropathy; study; induced peripheral ... See more keywords
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Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats

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recommendations! Published in 2017 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.05.069

Abstract: Paclitaxel induces peripheral neuropathy, which is dose-limiting and results in loss of quality of life. Therefore, the prevention and treatment of paclitaxel-induced peripheral neuropathy are major concerns in clinical cancer therapy. However, the detailed mechanisms… read more here.

Keywords: paclitaxel induced; peripheral neuropathy; expression; mechanical allodynia ... See more keywords
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Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy

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recommendations! Published in 2019 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2018.11.027

Abstract: ABSTRACT Paclitaxel chemotherapy treatment often leads to neuropathic pain resistant to available analgesic treatments. Recently spinal Toll‐like receptor 4 (TLR4) and the transient receptor potential cation channel subfamily V member 1 (TRPV1) were identified to… read more here.

Keywords: capsaicin; pi3k; paclitaxel induced; mechanical allodynia ... See more keywords
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Role of GABAB receptors and p38MAPK/NF-κB pathway in paclitaxel-induced apoptosis of hippocampal neurons

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recommendations! Published in 2017 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2017.1392987

Abstract: Abstract Context: The effects of the anticancer drug paclitaxel on learning and memory are rarely studied. Objective: This study investigated changes in GABAB receptor expression during paclitaxel-induced apoptosis of hippocampal neurons and the role of… read more here.

Keywords: paclitaxel induced; induced apoptosis; hippocampal neurons; p38mapk pathway ... See more keywords