Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22845
Abstract: Diabetic retinopathy (DR) is a common diabetic complication known to cause vision impairment and blindness. Previous studies have demonstrated that proanthocyanidins (PACs), polyphenols that are naturally found in several plants and fruits, have powerful antioxidant… read more here.
Keywords: nlrp3 inflammasome; high glucose; pacs; glucose induced ... See more keywords
Dynamics and sources of pharmaceutically active compounds in a coastal Mediterranean river during heavy rains
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-0880-7
Abstract: Concentrations of pharmaceutically active compounds (PACs) in freshwater systems depend on numerous factors such as land use and hydrometeorological conditions. In the Mediterranean, heavy rain events are of particular importance as they highly influence the… read more here.
Keywords: river; active compounds; pharmaceutically active; coastal mediterranean ... See more keywords
PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.085
Abstract: The regulated secretory pathway is a specialized form of protein secretion found in endocrine and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that utilizes this pathway to be trafficked to dense core secretory granules… read more here.
Keywords: protein; adaptor protein; secretory pathway; pacs ... See more keywords
Life's Simple 7 cardiovascular health score and premature atrial contractions: The atherosclerosis risk in communities (ARIC) study.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2021.02.083
Abstract: BACKGROUND Premature atrial contractions (PACs) are associated with increased risk of atrial fibrillation (AF) and ischemic stroke. Although lifestyle and risk factor modification reduces AF incidence, their relationship to PACs frequency is unclear. We assessed… read more here.
Keywords: risk; pacs frequency; life; score ... See more keywords
Determination of 27 metals in HISS-1, MESS-4 and PACS-3 marine sediment certified reference materials by the BCR sequential extraction.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2020.121543
Abstract: The BCR sequential extraction procedure developed by the European Community Bureau of Reference was applied to the three marine sediment certified reference materials (CRMs). These CRMs are designated as HISS-1, MESS-4, and PACS-3 and comprise… read more here.
Keywords: extraction; sequential extraction; reference; mess ... See more keywords
Characterization of Polycyclic Aromatic Compounds in Commercial Pavement Sealcoat Products for Enhanced Source Apportionment.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b06779
Abstract: Coal tar-based sealcoat (CTSC) products are an urban source of polycyclic aromatic compounds (PACs) to the environment. However, efforts to assess the environmental fate and impacts of CTSC-derived PACs are hindered by the ubiquity of… read more here.
Keywords: source; aromatic compounds; sealcoat products; polycyclic aromatic ... See more keywords
Synthesis of A-type Proanthocyanidins and their Analogues. A Comprehensive Review.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c03380
Abstract: Proanthocyanidins (PACs) are oligomers or polymers composed of units of flavanols. A-type proanthocyanidins are a subclass of PACs characterized by the presence of at least a double linkage between two consecutive monomers of flavanol. These… read more here.
Keywords: synthesis type; review; type proanthocyanidins; type pacs ... See more keywords
Chemical Transformation of B- to A-type Proanthocyanidins and 3D Structural Implications.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c00231
Abstract: In nature, proanthocyanidins (PACs) with A-type linkages are relatively rare, likely due to biosynthetic constraints in the formation of additional ether bonds to be introduced into the more common B-type precursors. However, A-type linkages confer… read more here.
Keywords: type linkages; type proanthocyanidins; pacs; type ... See more keywords
PACS-1 Interacts with TRPC3 and ESyt1 to Mediate Protein Trafficking while Promoting SOCE and Cooperatively Regulating Hormone Secretion
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c04998
Abstract: Corticotropic cells of the anterior pituitary gland release adrenocorticotropic hormone (ACTH) in a regulated manner to promote the production of cortisol and androgens. The process of ACTH secretion is partly mediated by the phosphofurin acidic… read more here.
Keywords: soce; pacs; acth secretion; protein ... See more keywords
Depth-corrected multi-factor dissection of chromatin accessibility for scATAC-seq data with PACS
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55580-5
Abstract: Single cell ATAC-seq (scATAC-seq) experimental designs have become increasingly complex, with multiple factors that might affect chromatin accessibility, including genotype, cell type, tissue of origin, sample location, batch, etc., whose compound effects are difficult to… read more here.
Keywords: seq data; chromatin accessibility; pacs; scatac seq ... See more keywords
Akkermansia muciniphila MucT harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64477-w
Abstract: Dietary proanthocyanidins (PACs) are polyphenols that promote a healthy gut microbiome. PACs are notable for their rich catechol moieties with high affinity for iron, enabling them to interfere with pathogens’ iron uptake. PACs selectively increase… read more here.
Keywords: iron uptake; iron; pacs; akkermansia muciniphila ... See more keywords