Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4727
Abstract: Cobll1 affects blast crisis (BC) progression and tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML). PACSIN2, a novel Cobll1 binding protein, activates TKI‐induced apoptosis in K562 cells, and this activation is suppressed by… read more here.
Keywords: pacsin2 sh3bp1; resistance; pacsin2; cobll1 pacsin2 ... See more keywords
PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-06-0352
Abstract: Apical microvilli are critical for the homeostasis of transporting epithelia, yet mechanisms that control the assembly and morphology of these protrusions remain poorly understood. Previous studies in intestinal epithelial cell lines suggested a role for… read more here.
Keywords: microvilli; dependent apical; endocytosis; pacsin2 dependent ... See more keywords
PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201610
Abstract: This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models. PACSIN2 variants are associated with gastrointestinal effects of thiopurines and thiopurine methyltransferase activity through… read more here.
Keywords: mercaptopurine cytotoxicity; cytotoxicity; intestinal cells; pacsin2 ... See more keywords