Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum
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DOI: 10.1007/s00253-018-9375-9
Abstract: Pactamycin, a structurally unique aminocyclitol natural product isolated from Streptomyces pactum, has potent antibacterial, antitumor, and anti-protozoa activities. However, its production yields under currently used culture conditions are generally low. To understand how pactamycin biosynthesis… read more here.
Keywords: production; pactamycin; pactamycin biosynthesis; streptomyces pactum ... See more keywords
Approach to pactamycin analogues using rhodium(II)-catalyzed alkene aziridination and C(sp3)–H amination reactions
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DOI: 10.1039/c7qo00878c
Abstract: Dirhodium(II)-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp3)–H amination and alkene aziridination reactions, the latter followed by a… read more here.
Keywords: alkene aziridination; pactamycin; sp3 amination;