Synthesis of reversible PAD4 inhibitors via copper-catalyzed C−H arylation of benzimidazole
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9409-3
Abstract: PAD4 is a promising epigenetic drug target for various cancers and immune diseases. In this work, we applied a Cu-catalyzed C–H arylation reaction of N-heteroarene to the synthesis of complex non-covalent PAD4 inhibitors bearing a… read more here.
Keywords: pad4; synthesis; pad4 inhibitors; catalyzed arylation ... See more keywords
PAD4 and Its Inhibitors in Cancer Progression and Prognosis
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DOI: 10.3390/pharmaceutics14112414
Abstract: The systemic spread of malignancies and the risk of cancer-associated thrombosis are major clinical challenges in cancer therapy worldwide. As an important post-translational modification enzyme, peptidyl arginine deiminase 4 (PAD4) could mediate the citrullination of… read more here.
Keywords: cancer; pad4 inhibitors; prognosis; associated thrombosis ... See more keywords