Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Rheumatology"
DOI: 10.1080/03009742.2018.1488273
Abstract: Objective: Peptidylarginine deiminase-4 (PAD4) is highly expressed by neutrophils and essential for citrullination occurring during the formation of neutrophil extracellular traps, which have been implicated in the pathogenesis of systemic lupus erythematosus (SLE) and lupus… read more here.
Keywords: padi4; systemic lupus; lupus erythematosus; lupus nephritis ... See more keywords
PADI4 and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus and juvenile idiopathic arthritis, a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033700
Abstract: Background: This study evaluated the association between peptidyl arginine deiminase type IV (PADI4) and interleukin 33 (IL-33) with systemic lupus erythematosus (SLE) and juvenile idiopathic arthritis (JIA). Method: We searched the PubMed, Web of Science,… read more here.
Keywords: padi4; systemic lupus; model; association ... See more keywords
Abstract 1916: Peptidylarginine deiminase IV (PADI4) is a novel tumor suppressor that may contribute to regulation of breast cancer stem cell dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1916
Abstract: Breast cancer is a global problem that accounts for almost a fourth of all cancers in women. Despite the many therapeutic strategies currently in use, treated patients often suffer from cancer relapse and metastasis due… read more here.
Keywords: padi4; breast cancer; cancer; stem ... See more keywords
Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis
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DOI: 10.1242/bio.059143
Abstract: Peptidylarginine deiminases (PADIs) are strongly associated with the development of autoimmunity, neurodegeneration and cancer but their physiological roles are ill-defined. The nuclear deiminase PADI4 regulates pluripotency in the mammalian pre-implantation embryo but its function in… read more here.
Keywords: peptidylarginine; function; padi4 dispensable; development ... See more keywords
CircRNA hsa_circ_0008500 Acts as a miR-1301-3p Sponge to Promote Osteoblast Mineralization by Upregulating PADI4
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.602731
Abstract: Circular RNAs (circRNAs) are regarded as pivotal regulators in bone metabolism. However, the role of circRNAs in osteoblast mineralization remains largely unknown. Herein, we explored the expression profiles of circRNAs in 4 groups of osteoblasts… read more here.
Keywords: osteoblast mineralization; circ 0008500; padi4; mir 1301 ... See more keywords
Inhibitory effects of ubiquitination of synoviolin by PADI4.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7764
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory articular disease that is characterized by synovial hyperplasia. A number of signaling pathways are associated with the development and induced symptoms of RA. Notably, patients with RA have… read more here.
Keywords: inhibitory effects; padi4; citrullination; citrullinated proteins ... See more keywords