Fusion of engineered albumin with factor IX Padua extends half‐life and improves coagulant activity
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17559
Abstract: The short half‐life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)‐mediated recycling of the chimera. However,… read more here.
Keywords: life; padua; fusion; half life ... See more keywords
The Complete Dependence of Factor IX Padua (R338L) Hyperactivity on Factor VIIIa Cofactor Activity Supports Its Safety As a Transgene for Hemophilia B Gene Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119270
Abstract: Factor IX (FIX) Padua (R338L) has been described as a game changer for hemophilia B (HB) gene therapy. The ~8-fold increased specific activity compared to wild-type FIX (FIX WT) in aPTT-based clotting assay has recently… read more here.
Keywords: activity; gene therapy; fix padua; padua ... See more keywords
Investigation of the Differences in Antithrombin to Heparin Binding among Antithrombin Budapest 3, Basel, and Padua Mutations by Biochemical and In Silico Methods
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DOI: 10.3390/biom11040544
Abstract: Antithrombin (AT) is a serine protease inhibitor, its activity is highly accelerated by heparin. Mutations at the heparin-binding region lead to functional defect, type II heparin-binding site (IIHBS) AT deficiency. The aim of this study… read more here.
Keywords: silico methods; differences antithrombin; heparin binding; investigation differences ... See more keywords
Perioperative Prevention of Venous Thromboembolism in Abdominal Surgery Patients Based on the Caprini or the Padua Risk Score—A Single Centre Prospective Observational Study
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111843
Abstract: Surgical patients should receive perioperative thromboprophylaxis based on risk assessment, and the Caprini score is validated for this purpose. Whether the Padua score, originally devised for medical patients, can be useful in surgical patients remains… read more here.
Keywords: padua; caprini padua; padua score; risk ... See more keywords
Post-meeting report of the 2022 On-site Padua Days on Muscle and Mobility Medicine, March 30 - April 3, 2022, Padua, Italy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Translational Myology"
DOI: 10.4081/ejtm.2022.10521
Abstract: Despite COVID-19 outbreak, the program of the 2022 Padua Days of Muscle and Mobility Medicine (PDM3) was confirmed On-site in February from March 30 to April 2, 2022 to be held at the University of… read more here.
Keywords: padua; march; myology; program ... See more keywords
The associations of RENAL, PADUA and C-index nephrometry scores with perioperative outcomes and postoperative renal function in minimally invasive partial nephrectomy.
Sign Up to like & getrecommendations! Published in 2020 at "Turkish journal of urology"
DOI: 10.5152/tud.2020.20247
Abstract: OBJECTIVE This study aimed to assess the utility of the radius, exophytic/endophytic, nearness, anterior/posterior, location (RENAL); preoperative aspects and dimensions used for an anatomic evaluation (PADUA), and centrality index (C-index) scores for the outcomes of… read more here.
Keywords: partial nephrectomy; index; perioperative outcomes; padua ... See more keywords