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   Articles with "paeoniflorin" as a keyword



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Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress

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recommendations! Published in 2019 at "Psychopharmacology"

DOI: 10.1007/s00213-019-05257-5

Abstract: Rationale and objectivePaeoniflorin has been reported to exhibit antidepressant-like effects in several animal model depression; and it also exerts a neuroprotective effect. In the present study, we investigated the effects of paeoniflorin administration on depression-like… read more here.

Keywords: subjected chronic; paeoniflorin; chronic unpredictable; mice subjected ... See more keywords
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Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway

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recommendations! Published in 2020 at "Molecular Neurobiology"

DOI: 10.1007/s12035-020-02144-5

Abstract: Nod-like receptor protein 3 (NLRP3)-associated neuroinflammation mediated by activated microglia is involved in the pathogenesis of depression. The role of the pore-forming protein gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome… read more here.

Keywords: depression; casp; paeoniflorin; pyroptosis ... See more keywords
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Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway.

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recommendations! Published in 2020 at "Acta histochemica"

DOI: 10.1016/j.acthis.2020.151649

Abstract: As one of the most frequent diabetic complications, diabetic foot ulcer (DFU) can cause limb ischemia or even amputation. Paeoniflorin (PF) has been reported to possess many kinds of biological functions, such as antioxidant and… read more here.

Keywords: wound healing; paeoniflorin; dfu; nrf2 pathway ... See more keywords
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Eudragit S100-coated halloysite nanotube/chitosan microspheres for colon-targeted release of paeoniflorin

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recommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2020.102258

Abstract: Abstract Paeoniflorin is a promising therapy for ulcerative colitis; however, a carrier is required for its localization and release in the colon. This study was conducted to investigate the colon-targeting potential of Eudragit S100 (EUS100)-coated… read more here.

Keywords: eudragit s100; paeoniflorin; hnt cts; colon ... See more keywords
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Simultaneous determination of calycosin‐7‐O‐&bgr;‐D‐glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC‐MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction

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recommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2019.03.022

Abstract: HighlightsDevelopment of UHPLC‐MS/MS method for simultaneous determination of four active constituents in rat plasma.The method was successfully applied to a pharmacokinetic study of HGWWD.PK profiles of the four analytes of HGWWD were revealed for the… read more here.

Keywords: paeoniflorin; cinnamic acid; bgr glucoside; calycosin bgr ... See more keywords
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Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2024325

Abstract: ABSTRACT Pregnancy-induced hypertension (PIH) is a leading cause of maternal mortality. Paeoniflorin has been reported to alleviate hypertension, thus relieving the injury of target organ. This study aimed to investigate the role of paeoniflorin in… read more here.

Keywords: damage; hypertension; paeoniflorin; gestational hypertension ... See more keywords
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Diversity of endophytic fungi of Paeonia lactiflora Pallas and screening for fungal paeoniflorin producers

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recommendations! Published in 2018 at "FEMS Microbiology Letters"

DOI: 10.1093/femsle/fny263

Abstract: Endophytic fungi from Paeonia lactiflora Pallas, which is mainly distributed in China, were characterized and screened to identify those capable of producing paeoniflorin. A total of 101 isolates obtained from the roots, stems and leaves… read more here.

Keywords: lactiflora pallas; paeoniflorin; fungi paeonia; endophytic fungi ... See more keywords
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Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma

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recommendations! Published in 2019 at "BioMed Research International"

DOI: 10.1155/2019/9053295

Abstract: Paeoniflorin (PF), as one of the important valid natural compounds of the total glucosides of peony, has displayed a potential effect in cancer prevention and treatment. Aggressive migration and invasion, as an important process, can… read more here.

Keywords: paeoniflorin; invasion; invasion actin; rearrangement ... See more keywords
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Paeoniflorin Can Improve Acute Lung Injury Caused by Severe Acute Pancreatitis through Nrf2/ARE Pathway

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recommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"

DOI: 10.1155/2022/5712219

Abstract: Objective To evaluate the potential therapeutic effect of paeoniflorin on acute lung injury induced by severe acute pancreatitis (SAP) and to initially explore the possible protective mechanisms of paeoniflorin. Method The SAP lung injury rat… read more here.

Keywords: acute lung; acute; lung injury; paeoniflorin ... See more keywords
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Paeoniflorin Attenuated TREM-1-Mediated Inflammation in THP-1 Cells

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recommendations! Published in 2022 at "Journal of Healthcare Engineering"

DOI: 10.1155/2022/7051643

Abstract: Sepsis is caused by bacterial infections or viral infections. Clinically, there exist confirmed or highly suspected infection foci. Mortality caused by septic shock remains in a high rate even though antibiotic treatment works effectively. In… read more here.

Keywords: trem mediated; mediated inflammation; thp cells; paeoniflorin ... See more keywords
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Paeoniflorin Antagonizes TNF-α-Induced L929 Fibroblastoma Cells Apoptosis by Inhibiting NF-κBp65 Activation

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recommendations! Published in 2018 at "Dose-Response"

DOI: 10.1177/1559325818774977

Abstract: Paeoniflorin (PF) is one of the main pharmacodynamic components of Paeonia suffruticosa Andr, which has a significant anti-inflammatory effect on rheumatoid arthritis (RA), with a mechanism related to the tumor necrosis factor α (TNF-α). The… read more here.

Keywords: paeoniflorin; tnf; apoptosis; tnf induced ... See more keywords