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   Articles with "paeonol" as a keyword



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Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway

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recommendations! Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.21993

Abstract: Neuropathic pain affects millions of people in the worldwide, but the major therapeutics perform limited effectiveness. Paeonol (PAE) is widely distributed in Paeonis albiflora, and has manifested anti‐inflammatory and antioxidative effects in multiple diseases. The… read more here.

Keywords: hdac mir; paeonol; astrocytic activation; constriction injury ... See more keywords
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Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities.

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recommendations! Published in 2022 at "Pest management science"

DOI: 10.1002/ps.6985

Abstract: BACKGROUND Paeonol is extracted and isolated as a rich and sustainable natural bioresource from the root bark of Paeonia suffruticosa, the derivatives of which exhibit numerous biological activities. It is well known that ester compounds… read more here.

Keywords: ester derivatives; paeonol ester; nematicidal anti; paeonol ... See more keywords
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Paeonol ameliorates monosodium urate‐induced arthritis in rats through inhibiting nuclear factor‐κB‐mediated proinflammatory cytokine production

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recommendations! Published in 2019 at "Phytotherapy Research"

DOI: 10.1002/ptr.6472

Abstract: Moutan Cortex has been widely used to treat various types of arthritis in traditional Chinese medicine. Paeonol is isolated as an active ingredient from Moutan Cortex. However, the effect and potential mechanism of paeonol on… read more here.

Keywords: induced arthritis; paeonol; rats inhibiting; mia rats ... See more keywords
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Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies

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recommendations! Published in 2017 at "Inflammation"

DOI: 10.1007/s10753-017-0611-8

Abstract: Paeonol, the main active component isolated from the root of Paeonia suffruticosa, has been reported to have anti-inflammatory properties. However, the effects of paeonol on osteoarthritis (OA) remain unclear. The aim of this study was… read more here.

Keywords: paeonol; mmp mmp; inflammation; pi3k akt ... See more keywords
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Paeonol regulates hypoxia‐induced proliferation of pulmonary artery smooth muscle cells via EKR 1/2 signalling

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recommendations! Published in 2018 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.07.017

Abstract: ABSTRACT Pulmonary hypertension (PH) is a disease with a developmental origin characterized by obstructive vascular remodelling that is partially due to excessive pulmonary arterial smooth muscle cells (PASMCs) proliferation. Paeonol has important effects on vascular… read more here.

Keywords: paeonol; proliferation; muscle cells; smooth muscle ... See more keywords
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Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway.

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recommendations! Published in 2018 at "Environmental toxicology and pharmacology"

DOI: 10.1016/j.etap.2018.04.016

Abstract: In this study, the beneficial effect of paeonol on acute alcohol-induced liver injury and the basic mechanisms were investigated. in vitro, HepG2 cells were treated with paeonol for 24 h before it were exposed to alcohol… read more here.

Keywords: paeonol; induced liver; alcohol induced; liver injury ... See more keywords
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Synthesis and evaluation of acetylferulic paeonol ester and ferulic paeonol ester as potential antioxidants to inhibit fish oil oxidation.

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recommendations! Published in 2021 at "Food chemistry"

DOI: 10.1016/j.foodchem.2021.130384

Abstract: Acetylferulic paeonol ester (APE) and ferulic paeonol ester (FPE) were synthesized, and their structures were confirmed by NMR, mass spectra, IR and UV-vis data. The antioxidant properties of the synthesized compounds were evaluated using 2,2-diphenyl-1-picrylhydrazyl… read more here.

Keywords: fish oil; paeonol; paeonol ester; oxidation ... See more keywords
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Measurement and Correlation of Paeonol Solubility in Supercritical Carbon Dioxide

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recommendations! Published in 2019 at "Journal of Chemical & Engineering Data"

DOI: 10.1021/acs.jced.9b00483

Abstract: Paeonol shows a wide range of pharmacological activities in the pharmaceutical industry. In this study, the solubility of paeonol in supercritical carbon dioxide (ScCO2) is determined by measuring the cloud-point pressures of the binary system… read more here.

Keywords: carbon dioxide; paeonol; solubility; supercritical carbon ... See more keywords
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Paeonol alleviates CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling

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recommendations! Published in 2019 at "Immunopharmacology and Immunotoxicology"

DOI: 10.1080/08923973.2019.1613427

Abstract: Abstract Objective: Paeonol is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities. We investigated the anti-fibrotic effect and underlying mechanism of paeonol. Methods: Twenty-four male C57BL/6J mice were… read more here.

Keywords: paeonol; smad3 signaling; tgf smad3; liver fibrosis ... See more keywords
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Effect of paeonol against bacterial growth, biofilm formation and dispersal of Staphylococcus aureus and Listeria monocytogenes in vitro

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recommendations! Published in 2022 at "Biofouling"

DOI: 10.1080/08927014.2022.2045014

Abstract: Abstract Previous studies have demonstrated the antibacterial activity of paeonol against bacterial pathogens, but its anti-biofilm activities against Staphylococcus aureus and Listeria monocytogenes remain largely unexplored. Here, the antibacterial and anti-biofilm activities of paeonol against… read more here.

Keywords: paeonol bacterial; microscopy; paeonol; staphylococcus aureus ... See more keywords
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Paeonol attenuates heart failure induced by transverse aortic constriction via ERK1/2 signalling

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recommendations! Published in 2022 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2022.2040543

Abstract: Abstract Context Paeonol (PAE) is the main phytochemical from Cortex Moutan. Its main pharmacological effects are anti-inflammatory and antioxidant, but its cardioprotective effect is unclear. Objective The study investigates the effects and underlying mechanisms of… read more here.

Keywords: transverse aortic; paeonol; showed pae; tac ... See more keywords