Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.01.006
Abstract: Summary RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymerase-associated factor 1 (Paf1), but it is not known… read more here.
Keywords: transcript; elongation; transcription elongation; fate ... See more keywords
Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00865
Abstract: The evolutionarily conserved RNA polymerase II-associated factor 1 (Paf1) from yeast to humans regulates transcription and associated processes, and thus, malfunctions and/or misregulations of Paf1 are associated with cellular pathologies. Indeed, Paf1 (also known as… read more here.
Keywords: evolutionarily conserved; rna polymerase; factor; conserved rna ... See more keywords
Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06237-7
Abstract: The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex (Paf1C), which is composed of at least five subunits (Paf1, Leo1, Ctr9, Cdc73, and Rtf1), plays vital roles in gene regulation and has connections to development… read more here.
Keywords: ctr9 paf1; paf1 complex; paf1 ctr9; ctr9 ... See more keywords
Paf1C regulates RNA polymerase II progression by modulating elongation rate
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1904324116
Abstract: Significance The factors that regulate RNA polymerase II (Pol II) elongation rate and processivity are poorly understood. Here, we show that the Paf1 complex (Paf1C) modulates Pol II elongation rate, and loss of Paf1 results… read more here.
Keywords: pol elongation; rna polymerase; elongation; rate ... See more keywords
Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm5504
Abstract: Pleiotropic transcription regulator RNA polymerase II (Pol II)-associated factor 1 (PAF1) governs multiple transcriptional steps and the deposition of several epigenetic marks. However, it remains unclear how ultimate transcriptional outcome is determined by PAF1 and… read more here.
Keywords: polymerase; elongation; rna polymerase; progression ... See more keywords
PAF1 regulation of promoter-proximal pause release via enhancer activation
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan3269
Abstract: Multitalented enhancers Productive transcription from DNA demands initiation, elongation, and termination. Enhancers are DNA sequences that loop with promoters to initiate transcription. Chen et al. show that enhancers also regulate gene expression by modulating transcription… read more here.
Keywords: promoter proximal; release paused; enhancer activation; paf1 ... See more keywords
The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-11-815035
Abstract: Eleven-nineteen leukemia (ENL) is a chromatin reader present in complexes stimulating transcriptional elongation. It is fused to mixed-lineage leukemia (MLL) in leukemia, and missense mutations have been identified in Wilms tumor and acute myeloid leukemia.… read more here.
Keywords: polycomb silencing; paf1; leukemia; interaction enl ... See more keywords
Cdc73 suppresses genome instability by mediating telomere homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007170
Abstract: Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ… read more here.
Keywords: cdc73 suppresses; paf1 complex; paf1; cdc73 ... See more keywords