Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2017.08.003
Abstract: The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a diverse set of recent studies from various organisms that build… read more here.
Keywords: paf1 complex; emerging insights; roles paf1; insights roles ... See more keywords
Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
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DOI: 10.1038/s41467-018-06237-7
Abstract: The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex (Paf1C), which is composed of at least five subunits (Paf1, Leo1, Ctr9, Cdc73, and Rtf1), plays vital roles in gene regulation and has connections to development… read more here.
Keywords: ctr9 paf1; paf1 complex; paf1 ctr9; ctr9 ... See more keywords
Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad180
Abstract: Abstract The Paf1 complex (Paf1C) is a conserved transcription elongation factor that regulates transcription elongation efficiency, facilitates co-transcriptional histone modifications, and impacts molecular processes linked to RNA synthesis, such as polyA site selection. Coupling of… read more here.
Keywords: active genes; elongation; genes saccharomyces; paf1 complex ... See more keywords
Cdc73 suppresses genome instability by mediating telomere homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007170
Abstract: Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ… read more here.
Keywords: cdc73 suppresses; paf1 complex; paf1; cdc73 ... See more keywords