Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.03.025
Abstract: Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole… read more here.
Keywords: ubiquitin like; serine 119; like protein; tuberculosis ... See more keywords
Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00289
Abstract: Tuberculosis is caused by the bacterium Mycobacterium tuberculosis (Mtb) and is ranked as the second killer infectious disease after COVID-19. Proteasome accessory factor A (PafA) is considered an attractive target because of its low sequence… read more here.
Keywords: mycobacterium tuberculosis; pafa; tuberculosis; mtb ... See more keywords
Formation of liquid crystal/gel emulsions to nano-emulsions constructed by polyalkoxylated fatty alcohol (PAFA)-based mixed surfactant systems
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DOI: 10.1080/01932691.2018.1491859
Abstract: Abstract In the construction of ternary phase diagrams, the polyalkoxylated fatty alcohol (PAFA)-based mixed surfactant systems including PAFA-AS (alkyl sulfonate), PAFA-CB (cocamidopropyl betaine) and PAFA-APG (alkyl polyglucosides) were used to develop self-standing liquid crystal/gel emulsions… read more here.
Keywords: gel emulsions; formation; crystal gel; liquid crystal ... See more keywords