TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0120-427rr
Abstract: The Vγ9Vδ2 T cell subset is the major γδ T cell subset in human peripheral blood and has the unique ability to contribute to immune surveillance by detecting pyrophosphorylated metabolites of isoprenoid synthesis, termed phosphoantigens… read more here.
Keywords: pag; tcr repertoire; neonatal cells; proliferation ... See more keywords
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05650-5
Abstract: Opioid drugs are a first-line treatment for severe acute pain and other chronic pain conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co-administration of cannabinoids with opioid receptor agonists produce anti-nociceptive synergy, but… read more here.
Keywords: opioid receptor; morphine; anti nociceptive; receptor ... See more keywords
Impaired visceral pain-related functions of the midbrain periaqueductal gray in rats with colitis
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2022.02.002
Abstract: The midbrain periaqueductal gray (PAG) is a key structure involved in the supraspinal modulation of pain. Previous studies have reported the association of gut inflammation-triggered chronic abdominal pain with structural and neuronal alterations within the… read more here.
Keywords: visceral pain; midbrain periaqueductal; periaqueductal gray; pain ... See more keywords
Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans
Sign Up to like & getrecommendations! Published in 2017 at "Neuroimage"
DOI: 10.1016/j.neuroimage.2016.08.038
Abstract: Abstract Deep brain stimulation (DBS) of the periaqueductal gray (PAG) is used in the treatment of severe refractory neuropathic pain. We tested the hypothesis that DBS releases endogenous opioids to exert its analgesic effect using… read more here.
Keywords: endogenous opioids; deep brain; stimulation; dbs ... See more keywords
Nanoparticle filtration through microporous ECTFE membrane in an alcoholic solution
Sign Up to like & getrecommendations! Published in 2019 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2018.08.022
Abstract: Abstract Organic solvent filtration is an important industrial process. It is widely used in pharmaceutical manufacturing, chemical processing industry, semiconductor industry, auto assembly etc. Most of the particle filtration studies reported in open literature dealt… read more here.
Keywords: pag; filtration; membrane; solvent filtration ... See more keywords
Opioids and maternal brain–behavior adaptation
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00858-7
Abstract: Advances in noninvasive brain-imaging of parents with psychological, behavioral, and endocrine measures is pointing to new paradigms for conceptualizing and treating parents with mental illness, including opioid use disorder (OUD) [1]. From 1999 to 2014,… read more here.
Keywords: opioid receptor; treatment; buprenorphine; brain ... See more keywords
Paediatric and adolescent gynaecology services in a tertiary teaching hospital
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2020.1821617
Abstract: Abstract This was a retrospective review of a tertiary Paediatric and Adolescent Gynaecology (PAG) referral service catering to the South Yorkshire population in the UK. All patients referred to the PAG clinic from May 2014… read more here.
Keywords: gynaecology; adolescent gynaecology; paediatric adolescent; care ... See more keywords
Sustained and potent analgesia with negligible side effects enabled by adaptive individualized granular stimulation in rat brainstem
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/acd3b2
Abstract: Objectives. To clarify if an adaptive current stimulation protocol, in which current amplitude is modulated during continuous stimulation, provides better efficacy than constant current stimulation protocol with respect to analgesia caused by individualized stimulation in… read more here.
Keywords: analgesia; pag; side effects; pag drn ... See more keywords
Designer Receptor Exclusively Activated by Designer Drug (DREADD)-Mediated Activation of the Periaqueductal Gray Restores Nociceptive Descending Inhibition After Traumatic Brain Injury in Rats
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurotrauma"
DOI: 10.1089/neu.2024.0031
Abstract: Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. Clinical studies suggest that damage to the periaqueductal gray matter (PAG) following TBI, a principal center… read more here.
Keywords: receptor; brain; dreadd; pag ... See more keywords
Functional representation of trigeminal nociceptive input in the human periaqueductal gray
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adj8213
Abstract: The periaqueductal gray (PAG) is located in the mesencephalon in the upper brainstem and, as part of the descending pain modulation, is considered a crucial structure for pain control. Its modulatory effect on painful sensation… read more here.
Keywords: nociceptive input; pag; functional representation; periaqueductal gray ... See more keywords
Tribology Evaluation on a Four-Ball Tribometer Lubricated by Al2O3/PAG Nanolubricants
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Automotive and Mechanical Engineering"
DOI: 10.15282/ijame.21.1.2024.09.0855
Abstract: Nanolubricants can improve the tribological properties for application in automotive systems. By reducing the friction rate of the internal components with nanolubricants, the service life of a compressor used in automotive air conditioning (AAC) can… read more here.
Keywords: pag; tribology; friction; ball tribometer ... See more keywords