TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0120-427rr
Abstract: The Vγ9Vδ2 T cell subset is the major γδ T cell subset in human peripheral blood and has the unique ability to contribute to immune surveillance by detecting pyrophosphorylated metabolites of isoprenoid synthesis, termed phosphoantigens… read more here.
Keywords: pag; tcr repertoire; neonatal cells; proliferation ... See more keywords
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05650-5
Abstract: Opioid drugs are a first-line treatment for severe acute pain and other chronic pain conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co-administration of cannabinoids with opioid receptor agonists produce anti-nociceptive synergy, but… read more here.
Keywords: opioid receptor; morphine; anti nociceptive; receptor ... See more keywords
Impaired visceral pain-related functions of the midbrain periaqueductal gray in rats with colitis
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2022.02.002
Abstract: The midbrain periaqueductal gray (PAG) is a key structure involved in the supraspinal modulation of pain. Previous studies have reported the association of gut inflammation-triggered chronic abdominal pain with structural and neuronal alterations within the… read more here.
Keywords: visceral pain; midbrain periaqueductal; periaqueductal gray; pain ... See more keywords
Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans
Sign Up to like & getrecommendations! Published in 2017 at "Neuroimage"
DOI: 10.1016/j.neuroimage.2016.08.038
Abstract: Abstract Deep brain stimulation (DBS) of the periaqueductal gray (PAG) is used in the treatment of severe refractory neuropathic pain. We tested the hypothesis that DBS releases endogenous opioids to exert its analgesic effect using… read more here.
Keywords: endogenous opioids; deep brain; stimulation; dbs ... See more keywords
Nanoparticle filtration through microporous ECTFE membrane in an alcoholic solution
Sign Up to like & getrecommendations! Published in 2019 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2018.08.022
Abstract: Abstract Organic solvent filtration is an important industrial process. It is widely used in pharmaceutical manufacturing, chemical processing industry, semiconductor industry, auto assembly etc. Most of the particle filtration studies reported in open literature dealt… read more here.
Keywords: pag; filtration; membrane; solvent filtration ... See more keywords
Opioids and maternal brain–behavior adaptation
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00858-7
Abstract: Advances in noninvasive brain-imaging of parents with psychological, behavioral, and endocrine measures is pointing to new paradigms for conceptualizing and treating parents with mental illness, including opioid use disorder (OUD) [1]. From 1999 to 2014,… read more here.
Keywords: opioid receptor; treatment; buprenorphine; brain ... See more keywords
Paediatric and adolescent gynaecology services in a tertiary teaching hospital
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2020.1821617
Abstract: Abstract This was a retrospective review of a tertiary Paediatric and Adolescent Gynaecology (PAG) referral service catering to the South Yorkshire population in the UK. All patients referred to the PAG clinic from May 2014… read more here.
Keywords: gynaecology; adolescent gynaecology; paediatric adolescent; care ... See more keywords
Sustained and potent analgesia with negligible side effects enabled by adaptive individualized granular stimulation in rat brainstem
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/acd3b2
Abstract: Objectives. To clarify if an adaptive current stimulation protocol, in which current amplitude is modulated during continuous stimulation, provides better efficacy than constant current stimulation protocol with respect to analgesia caused by individualized stimulation in… read more here.
Keywords: analgesia; pag; side effects; pag drn ... See more keywords
A Novel Role for the Periaqueductal Gray in Consummatory Behavior
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2018.00178
Abstract: The periaqueductal gray (PAG) has a well-established role in pain processing, autonomic function and behavioral responses to fear. Anatomical work suggests the PAG may mediate food intake and reward processing as it has extensive reciprocal… read more here.
Keywords: pag; pag neurons; periaqueductal gray; role ... See more keywords
Between-subject similarity of functional connectivity-based organization of the human periaqueductal gray related to autonomic processing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1028925
Abstract: The periaqueductal gray (PAG) is a brain stem area designated to play an essential role in lower urinary tract (LUT) control. Post-mortem human and animal studies have indicated that the PAG is symmetrically organized in… read more here.
Keywords: periaqueductal gray; similarity; similarity functional; pag ... See more keywords
Assessment of Brainstem Functional Organization in Healthy Adults and Overactive Bladder Patients Using Ultra-High Field fMRI
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020403
Abstract: The pathophysiological mechanisms of overactive bladder syndrome (OAB) remain largely unknown, with major involvement of the central nervous system (CNS). The periaqueductal gray (PAG) is a brainstem area which is indicated to play an essential… read more here.
Keywords: brainstem; bladder; pag; overactive bladder ... See more keywords