Reduced monocyte adhesion to aortae of diabetic plasminogen activator inhibitor-1 knockout mice
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1057-z
Abstract: Objective and designTo determine the requirement of plasminogen activator inhibitor-1-knockout (PAI-1) for monocyte adhesion in animals and cells under diabetic conditions.Methods and subjectsMonocyte adhesion assay, enzyme-linked immunosorbent assay, and Western blotting were used in analyzing… read more here.
Keywords: pai; adhesion; mice; plasminogen activator ... See more keywords
Prognostic implications of the co-detection of the urokinase plasminogen activator system and osteopontin in patients with non-small-cell lung cancer undergoing radiotherapy and correlation with gross tumor volume
Sign Up to like & getrecommendations! Published in 2017 at "Strahlentherapie und Onkologie"
DOI: 10.1007/s00066-017-1255-1
Abstract: BackgroundThe urokinase plasminogen activator system (uPA, uPAR, PAI‑1) is upregulated in cancer and high plasma levels are associated with poor prognosis. Their interaction with hypoxia-related osteopontin (OPN) which is also overexpressed in malignant tumors suggests… read more here.
Keywords: pai; plasmaspiegel; der; mit ... See more keywords
Expression of urokinase-type plasminogen activator system in non-metastatic prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Urology"
DOI: 10.1007/s00345-019-03038-5
Abstract: To investigate the prognostic role of expression of urokinase-type plasminogen activator system members, such as urokinase-type activator (uPA), uPA-receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1), in patients treated with radical prostatectomy (RP) for prostate cancer… read more here.
Keywords: system; pai; activator; urokinase type ... See more keywords
Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas
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DOI: 10.1007/s00403-017-1738-z
Abstract: There is substantial evidence implicating the urokinase system in tissue remodeling during neo-vascularization, inflammation, tumor invasion, and metastasis. Regulated degradation of the extracellular matrix at the leading edge of migrating cells, mediated by uPA and… read more here.
Keywords: pai; skin; upa upar; expression ... See more keywords
Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-020-06054-x
Abstract: Purpose Elevated expression of PAI-1 has been widely linked with adverse outcomes in a variety of human cancers, such as breast, gastric and ovarian cancers, rendering PAI-1 a prognostic biomarker. As a result, several chemical… read more here.
Keywords: inhibitor; oleuropein natural; pai; breast cancer ... See more keywords
Marvelous abilities for polyhedral oligomeric silsesquioxane to improve tribological properties of polyamide-imide/polytetrafluoroethylene coatings
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science"
DOI: 10.1007/s10853-018-2475-1
Abstract: POSS-doped organic–inorganic nanocomposites (POSS referring to polyhedral oligomeric silsesquioxane) as a new generation of high-performance materials are of special significance, since they simultaneously possess the high rigidity and stability of inorganic species as well as… read more here.
Keywords: oligomeric silsesquioxane; pai; poss; polyamide imide ... See more keywords
Relationship of HbA1c with plasma atherogenic index and non-HDL cholesterol in patients with type 2 diabetes mellitus
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DOI: 10.1007/s13410-020-00884-7
Abstract: Purpose Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD). The plasma atherogenic index (PAI) has been suggested as a novel marker of atherosclerosis and coronary heart disease. The present… read more here.
Keywords: hdl cholesterol; pai; non hdl; cholesterol ... See more keywords
What factors have impact on glucocorticoid replacement in adrenal insufficiency: a real-life study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01386-3
Abstract: Purpose The impact of patient’s characteristics on glucocorticoid (GC) replacement therapy in adrenal insufficiency (AI) is poorly evaluated. Aims of this study were to assess the influence of sex and body weight on GC dosing… read more here.
Keywords: pai; adrenal insufficiency; life study; real life ... See more keywords
A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.12.005
Abstract: Plasminogen activator inhibitor-1 (PAI-1) is a labile molecule that exists in four different forms: active, latent, cleaved and target bound form. Although there have been many methods to measure the total PAI-1, the measurement of… read more here.
Keywords: activator inhibitor; pai; active form; novel elisa ... See more keywords
PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.014
Abstract: AIM This study intented to clarify the intracellular effect of PAI-1 on Non-small cell lung cancer (NSCLC) metastasis and the precise mechanism involved. METHODS The metastatic properties of NSCLC cells were determined by transwell assays… read more here.
Keywords: mir 34a; pai; metastasis; non small ... See more keywords
PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115310
Abstract: Glucocorticoid (GC) treatments induce osteoporosis and chronic GC treatments have been suggested to induce delayed bone repair; however, the mechanisms by which GC induces delayed bone repair remain unclear. We herein investigated the roles of… read more here.
Keywords: delayed bone; pai; bone repair; bone ... See more keywords