Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.
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DOI: 10.1053/j.gastro.2018.08.011
Abstract: BACKGROUND & AIMS Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. We studied mice… read more here.
Keywords: iec mice; mir34a; mice; pai1 ... See more keywords