Effects of (2R,6R)-hydroxynorketamine in assays of acute pain-stimulated and pain-depressed behaviors in mice
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DOI: 10.1371/journal.pone.0301848
Abstract: Ketamine has been shown to produce analgesia in various acute and chronic pain states; however, abuse liability concerns have limited its utility. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has been shown to produce antidepressant-like effects similar… read more here.
Keywords: pain depressed; pain; acute pain; locomotor activity ... See more keywords