Increased Neuroligin 2 Levels in the Postsynaptic Membrane in Spinal Dorsal Horn may Contribute to Postoperative Pain
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.04.028
Abstract: Neuroligin 2 is a synaptic cell adhesion molecule that is mainly located in inhibitory synapses and is crucial in the regulation of synapse function through protein-protein interactions. However, researchers have not clearly determined whether neuroligin… read more here.
Keywords: pain hypersensitivity; dorsal horn; postoperative pain; neuroligin ... See more keywords
Endoplasmic Reticulum Stress in the Dorsal Root Ganglion Contributes to the Development of Pain Hypersensitivity after Nerve Injury
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.08.005
Abstract: Little is known about the functional relationship between endoplasmic reticulum (ER) stress and development of pain hypersensitivity after nerve injury. The aim of this study was to investigate the role of ER stress in the… read more here.
Keywords: development pain; stress; pain hypersensitivity;
D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0433-3
Abstract: Chronic pain is a common and undertreated nonmotor symptom in Parkinson’s disease (PD). Although chronic pain is improved by L-dopa in some PD patients, the underlying mechanisms remain unclear. In this study, we established PD… read more here.
Keywords: pain hypersensitivity; superficial dorsal; mice; receptor ... See more keywords
Tmem45b is essential for inflammation- and tissue injury–induced mechanical pain hypersensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121989119
Abstract: Significance Persistent pain hypersensitivity associated with inflammation, surgery, trauma, and nerve injury interferes with physical and mental activities and impairs quality of life. Herein, we showed that the chemical ablation of isolectin B4-binding (IB4+) afferents… read more here.
Keywords: inflammation; mechanical pain; pain; pain hypersensitivity ... See more keywords
Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000002013
Abstract: Patients with neuropathic pain often experience exaggerated pain and anxiety. Central sensitization has been linked with the maintenance of neuropathic pain and may become an autonomous pain generator. Conversely, emerging evidence accumulated that central sensitization… read more here.
Keywords: pain hypersensitivity; anxiety; central sensitization; neuropathic pain ... See more keywords
Response to the Letter to the Editor
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Noninvasive Electrocardiology"
DOI: 10.1111/anec.12756
Abstract: We read with great interest the recently published paper by Slimani et al. [2] in PAIN . The authors investigated pain sensitivity in congenitally blind individuals, and found reduced pain thresholds as well as increased… read more here.
Keywords: slimani; pain hypersensitivity; congenitally blind; anxiety ... See more keywords
MiR‐101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP‐1 mediated MAPK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15532
Abstract: This study was performed to characterize the effect of microRNA‐101 (miR‐101) on the pain hypersensitivity in CCI rat models with the involvement of mitogen‐activated protein kinase phosphatase 1 (MKP‐1) in spinal cord microglial cells. The… read more here.
Keywords: pain hypersensitivity; mir 101; cci rat; hypersensitivity ... See more keywords
Development and preliminary evaluation of a short self-report measure of generalized pain hypersensitivity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pain Research"
DOI: 10.2147/jpr.s182287
Abstract: Purpose Generalized pain hypersensitivity is frequently observed in chronic pain conditions. Currently, identification is based on expert clinical opinion, and in very few cases combined with quantitative sensory testing. The objectives of this study were… read more here.
Keywords: self report; pain; short self; pain hypersensitivity ... See more keywords
Sleep Deprivation Related Changes of Plasma Oxytocin in Males and Female Contraceptive Users Depend on Sex and Correlate Differentially With Anxiety and Pain Hypersensitivity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2018.00161
Abstract: Disturbed sleep is known to substantially aggravate both the pain condition and the affective state of pain patients. The neurobiological mechanisms underlying these adverse effects are unknown. Oxytocin (OT), being largely involved in social and… read more here.
Keywords: plasma; sleep deprivation; pain hypersensitivity; anxiety ... See more keywords