Molecular Genetics of Kappa Opioids in Pain and Itch Sensations.
Sign Up to like & getrecommendations! Published in 2020 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_397
Abstract: The opioid peptides and their receptors have been linked to multiple key biological processes in the nervous system. Here we review the functions of the kappa opioid receptor (KOR) and its endogenous agonists dynorphins (Goldstein… read more here.
Keywords: genetics kappa; kappa opioids; genetics; molecular genetics ... See more keywords
Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2020.101894
Abstract: An accelerating basic science literature is providing key insights into the mechanisms by which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the Gi-coupled neuropeptide Y1 receptor (Y1). Y1… read more here.
Keywords: neuropeptide receptor; pain itch; spinal neuropeptide; chronic pain ... See more keywords
Astrocytes in chronic pain and itch
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-019-0218-1
Abstract: Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte ‘gliopathy’. Indeed, in recent years there has… read more here.
Keywords: astrocytes chronic; pain; pain itch; chronic pain ... See more keywords
Neuropathic symptoms of the ocular surface: dryness, pain, and itch
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000389
Abstract: Purpose of review This review aims to describe the recent findings on epidemiology, pathophysiology, and management of neuropathic symptoms of the ocular surface, with a focus on potential similarities between sensations of dry eye, pain… read more here.
Keywords: symptoms ocular; ocular surface; neuropathic symptoms; pain itch ... See more keywords
Neuropathic pain and itch: mechanisms in allergic conjunctivitis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000843
Abstract: Purpose of review Allergic conjunctivitis is highly prevalent and affects up to one third of the general population. The current understanding of the pathophysiology and therapeutic strategies center around the type 2 inflammatory pathway. However,… read more here.
Keywords: itch pain; itch; pain itch; allergic conjunctivitis ... See more keywords
Slick Potassium Channels Control Pain and Itch in Distinct Populations of Sensory and Spinal Neurons in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004163
Abstract: Background: Slick, a sodium-activated potassium channel, has been recently identified in somatosensory pathways, but its functional role is poorly understood. The authors of this study hypothesized that Slick is involved in processing sensations of pain… read more here.
Keywords: slick mice; mice; pain itch; lbx1 slick ... See more keywords
Efficacy of extracorporeal shockwave therapy in the treatment of postherpetic neuralgia
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000019516
Abstract: Abstract Established conventional treatments for postherpetic neuralgia (PHN) and postherpetic itch (PHI) are difficult and often disappointing. In this study, the authors investigated the effect and mechanisms of extracorporeal shockwave therapy (ESWT) on pain and… read more here.
Keywords: itch; pain itch; treatment; postherpetic neuralgia ... See more keywords
Learned Nocebo Effects on Cutaneous Sensations of Pain and Itch: A Systematic Review and Meta-analysis of Experimental Behavioral Studies on Healthy Humans
Sign Up to like & getrecommendations! Published in 2023 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000001194
Abstract: ABSTRACT Objective In past decades, the field of nocebo research has focused on studying how sensory perception can be shaped by learning. Nocebo effects refer to aggravated sensory experiences or increased sensitivity to sensations such… read more here.
Keywords: sensations pain; pain itch; meta analysis; nocebo effects ... See more keywords
The pain and the itch
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DOI: 10.1126/science.371.6529.580-s
Abstract: Itch Spinal and epidural morphine administration is used in the clinical setting as an analgesic for surgical procedures and in women during labor. However, delivery through these routes is associated with the development of itch.… read more here.
Keywords: itch; pain itch; morphine;
Neuroinflammation Involved in Diabetes-Related Pain and Itch
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.921612
Abstract: Diabetes mellitus (DM) is a global epidemic with increasing incidence, which results in diverse complications, seriously affects the patient quality of life, and brings huge economic burdens to society. Diabetic neuropathy is the most common… read more here.
Keywords: pain itch; neuroinflammation; diabetic neuropathy; itch ... See more keywords
Do individual psychological characteristics predict induction and generalization of nocebo and placebo effects on pain and itch?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.838578
Abstract: Background Nocebo and placebo effects, i.e., adverse or beneficial treatment effects, respectively, putatively due to expectancies can modulate pain and itch. These effects can generalize within the pain or itch modality. Predicting the induction and… read more here.
Keywords: pain itch; placebo effects; placebo; nocebo placebo ... See more keywords