Standard analgesics reverse burrowing deficits in a rat CCI model of neuropathic pain, but not in models of type 1 and type 2 diabetes-induced neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.04.049
Abstract: Background: Burrowing is a rodent behavior validated as a robust and reproducible outcome measure to infer the global effect of pain in several inflammatory pain models. However, less is known about the effect of analgesics… read more here.
Keywords: burrowing deficits; model; neuropathic pain; pain models ... See more keywords
Chronic pain models amplify transient receptor potential vanilloid 1 (TRPV1) receptor responses in adult rat spinal dorsal horn
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107753
Abstract: Persistent pain is associated with negative affect originating from hypersensitivity and/or allodynia. The spinal cord is a key area for nociception as well as chronic pain processing. Specifically, the dorsal horn neurons in lamina II… read more here.
Keywords: trpv1; dorsal horn; pain models; receptor ... See more keywords
Pain reduction in validated rat pain models: radio frequency spectrum targeted at the low and ultra-low ends using the emulate® delivery system
Sign Up to like & getrecommendations! Published in 2022 at "Electromagnetic Biology and Medicine"
DOI: 10.1080/15368378.2022.2131568
Abstract: ABSTRACT EMulate Therapeutics, Inc. (EMTx) has developed a technology to deliver time-varying magnetic fields as WAV files, emitted in the extremely low through the low spectrum of radio frequencies (DC to 22 kHz), that can… read more here.
Keywords: rat; validated rat; pain models; spectrum ... See more keywords
Migraine and peripheral pain models show differential alterations in neuronal complexity
Sign Up to like & getrecommendations! Published in 2022 at "Headache"
DOI: 10.1111/head.14352
Abstract: Our laboratory has recently shown that there is a decrease in neuronal complexity in head pain processing regions in mouse models of chronic migraine‐associated pain and aura. Importantly, restoration of this neuronal complexity corresponds with… read more here.
Keywords: pain models; neuronal complexity; pain; migraine peripheral ... See more keywords
A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models
Sign Up to like & getrecommendations! Published in 2017 at "BMC Veterinary Research"
DOI: 10.1186/s12917-017-1151-z
Abstract: BackgroundOsteoarthritis (OA) is a common progressive joint disease in dogs and cats. The goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function. Currently, non-steroidal anti-inflammatory drugs (e.g., meloxicam) are the… read more here.
Keywords: treatment; pea; inflammation; inflammatory ... See more keywords
Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.968976
Abstract: Korean scientists have shown that oral administration of Angelica gigas Nakai (AGN) root alcoholic extract and the metabolite of its pyranocoumarins, decursinol, have antinociceptive properties across various thermal and acute inflammatory pain models. The objectives… read more here.
Keywords: antinociception; pain models; neuropathic pain; tolerance ... See more keywords