Gonadal hormone-dependent nociceptor sensitization maintains nociplastic pain state in female mice.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002715
Abstract: ABSTRACT Nociplastic pain conditions develop predominantly in women. We recently established a murine nociplastic pain model by applying postinjury thermal (40°C) stimulation to an injured (capsaicin-injected) area, triggering a transition to a nociplastic pain state… read more here.
Keywords: nociplastic pain; pain state; area; pain ... See more keywords
Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.593647
Abstract: The antinociceptive effect of methadone in the morphine-resistant inflammatory pain state was described in the paw-withdrawal test using the complete Freund’s adjuvant (CFA)-induced mouse inflammatory pain model. After intraplantar (i.pl.) injection of CFA, thermal hyperalgesia… read more here.
Keywords: morphine antinociception; morphine; inflammatory pain; methadone ... See more keywords