Anxiety affects disability and quality of life in patients with painful diabetic neuropathy
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DOI: 10.1002/ejp.1067
Abstract: Painful diabetic neuropathy (PDN) is known to negatively affect psychosocial functioning as expressed by enhanced levels of anxiety and depression. The aim of this study was to specify diabetes and pain‐related fears. read more here.
Keywords: disability quality; painful diabetic; diabetic neuropathy; affects disability ... See more keywords
Histone deacetylase 5‐induced deficiency of signal transducer and activator of transcription‐3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24328
Abstract: Diabetes patients with painful diabetic neuropathy (PDN) show severe spinal atrophy, suggesting pathological changes of the spinal cord contributes to central sensitization. However, the cellular changes and underlying molecular mechanisms within the diabetic spinal cord… read more here.
Keywords: diabetic neuropathy; spinal astrocytes; signal transducer; painful diabetic ... See more keywords
Neuromodulation Interventions for the Treatment of Painful Diabetic Neuropathy: a Systematic Review
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DOI: 10.1007/s11916-022-01035-9
Abstract: Painful diabetic neuropathy (PDN) is a prevalent and debilitating condition, characterized by severe burning, tingling, and lancinating pain usually located in the distal lower extremities. In addition to manifesting with severe pain, PDN may also… read more here.
Keywords: interventions treatment; neuromodulation interventions; diabetic neuropathy; treatment ... See more keywords
A Consideration of the Psychological Aspects to Managing Patients with Painful Diabetic Neuropathy: An Insight into Pain Management Services at a Tertiary Centre in the UK
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00983-y
Abstract: Painful diabetic neuropathy (pDN) is characterised by both sensory and affective disturbances, suggesting a complex bidirectional relationship of neuropathic pain and mood disorders. Data on pDN indicate that neuropathic pain reduces quality of life, including… read more here.
Keywords: painful diabetic; diabetic neuropathy; pain management; management ... See more keywords
A new look at painful diabetic neuropathy.
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2018.08.020
Abstract: The prevalence of diabetes mellitus and its chronic complications continue to increase alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical polyneuropathy (DSPN) and its sequelae, will also likely rise. Up to 50% of patients… read more here.
Keywords: painful diabetic; painful dspn; new look; diabetic neuropathy ... See more keywords
The relationship between painful diabetic peripheral neuropathy and functional status of older people in Kuantan, Pahang.
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DOI: 10.1016/j.enfcli.2020.12.007
Abstract: This study aimed to determine the relationship between painful diabetic peripheral neuropathy and functional status among older people in Kuantan, Pahang. A cross-sectional study was performed by using an interviewer-administered questionnaire among 300 participants recruited… read more here.
Keywords: painful diabetic; peripheral neuropathy; functional status; relationship ... See more keywords
Glycemic and serum lipid control in patients with painful diabetic peripheral neuropathy treated with pregabalin.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2016.03.019
Abstract: AIM To evaluate pregabalin effects on glycemic (hemoglobin A1c [HbA1c] and glucose) and lipid (low- and high-density lipoprotein [LDL and HDL, respectively], and total cholesterol, and triglycerides) control in patients with painful diabetic peripheral neuropathy… read more here.
Keywords: painful diabetic; control patients; control; patients painful ... See more keywords
A pharmacoeconomic evaluation of the pharmacotherapeutic options for painful diabetic neuropathy
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DOI: 10.1080/14656566.2022.2032647
Abstract: ABSTRACT Introduction Painful diabetic neuropathy (PDN) is a high incidence and severe complication of diabetes mellitus, significantly compromising patients’ quality of life and causing tremendous economic burden. Considering drug costs becomes part of treatment decisions,… read more here.
Keywords: pharmacotherapeutic options; evaluation pharmacotherapeutic; diabetic neuropathy; treatment ... See more keywords
Efficacy and safety of EMA401 in peripheral neuropathic pain: results of two randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy.
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DOI: 10.1097/j.pain.0000000000002252
Abstract: ABSTRACT The analgesic efficacy and safety of two Phase 2b studies of EMA401 (a highly selective angiotensin II type 2 receptor antagonist), in patients with postherpetic neuralgia (PHN; EMPHENE) and painful diabetic neuropathy (EMPADINE) were… read more here.
Keywords: painful diabetic; efficacy safety; phase studies; patients postherpetic ... See more keywords
Two-Point Discrimination Predicts Pain Relief after Lower Limb Nerve Decompression for Painful Diabetic Peripheral Neuropathy
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DOI: 10.1097/prs.0000000000004171
Abstract: Background: Peripheral nerve decompression surgery has been reported to be effective for pain reduction in patients with painful diabetic peripheral neuropathy. The aim of this study was to characterize which patients may have more pain… read more here.
Keywords: nerve decompression; relief; painful diabetic; peripheral neuropathy ... See more keywords
Restoration of aquaporin-4 polarization in the spinal glymphatic system by metformin in rats with painful diabetic neuropathy
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DOI: 10.1097/wnr.0000000000001880
Abstract: Painful diabetic neuropathy (PDN) is a common complication in patients with diabetes, and its underlying mechanism remains unclear. Aquaporin-4 (AQP4) plays a crucial role in removing metabolic waste in the glymphatic system. In this study,… read more here.
Keywords: system; spinal glymphatic; painful diabetic; polarization ... See more keywords