A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy.
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DOI: 10.1097/j.pain.0000000000002159
Abstract: ABSTRACT Diabetes is a leading cause of peripheral neuropathy (diabetic peripheral neuropathy, DPN), and uncontrolled long-lasting hyperglycemia leads to severe complications. A major proportion of diabetics develop excruciating pain with a variable course. Mechanisms leading… read more here.
Keywords: genome wide; painful dpn; mir mir; dpn ... See more keywords
The characteristics of pain and dysesthesia in patients with diabetic polyneuropathy
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DOI: 10.1371/journal.pone.0263831
Abstract: Introduction/aims Patients with diabetic polyneuropathy (DPN) may experience paresthesia, dysesthesia, and pain. We aimed to characterize the predictors, symptoms, somatosensory profile, neuropathy severity, and impact of painful DPN and dysesthetic DPN. Methods This study was… read more here.
Keywords: patients diabetic; pain dysesthesia; dpn; painful dpn ... See more keywords
Structural Brain Alterations in Key Somatosensory and Nociceptive Regions in Diabetic Peripheral Neuropathy.
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DOI: 10.2337/dc22-1123
Abstract: OBJECTIVE Despite increasing evidence demonstrating structural and functional alterations within the central nervous system in diabetic peripheral neuropathy (DPN), the neuroanatomical correlates of painful and painless DPN have yet to be identified. Focusing on structural… read more here.
Keywords: peripheral neuropathy; dpn; brain; painful dpn ... See more keywords
New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine
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DOI: 10.3389/fendo.2019.00929
Abstract: Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg amputation, and neuropathic pain (painful-DPN). Unfortunately, DPN is often diagnosed… read more here.
Keywords: medicine; precision medicine; painful dpn; early detection ... See more keywords