Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.01.011
Abstract: ABSTRACT Painful neuropathy, as a severe side effect of chemotherapeutic bortezomib, is the most common reason for treatment discontinuation. However, the mechanism by which administration of bortezomib leads to painful neuropathy remains unclear. In the… read more here.
Keywords: upregulation nlrp3; bortezomib; induced bortezomib; histone ... See more keywords
Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons
Sign Up to like & getrecommendations! Published in 2017 at "Pain"
DOI: 10.1097/j.pain.0000000000000939
Abstract: Abstract Painful neuropathy is the major dose-limiting side effect of paclitaxel chemotherapy. Mitochondrial dysfunction and adenosine triphosphate (ATP) deficit have previously been shown in peripheral nerves of paclitaxel-treated rats, but the effects of paclitaxel in… read more here.
Keywords: drg neurons; paclitaxel; dorsal root; deficit ... See more keywords
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients.
Sign Up to like & getrecommendations! Published in 2023 at "Pain"
DOI: 10.1097/j.pain.0000000000002905
Abstract: ABSTRACT Missing aspects of the heritability of chronic neuropathic pain, as a complex adult-onset trait, may be hidden within rare variants with low effect on disease risk, unlikely to be resolved by a single-variant approach.… read more here.
Keywords: rare variants; nociplastic pain; pain patients; chronic neuropathic ... See more keywords
Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0006
Abstract: Effective treatments for chemotherapy-induced peripheral neuropathy (CIPN) remain unavailable. Given the significance of spinal cord glutamate transporters in neuronal plasticity and central sensitization, this study investigated the role of excitatory amino acid transporter 2 (EAAT2)… read more here.
Keywords: glutamate; hdac2; paclitaxel induced; painful neuropathy ... See more keywords
PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22083927
Abstract: Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics, such as oxaliplatin (L-OHP). The aim of the present work was to evaluate the potential beneficial effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in a murine model… read more here.
Keywords: oxaliplatin induced; induced painful; pea oxa; oxa ... See more keywords