Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding.
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DOI: 10.1016/j.bpj.2021.01.016
Abstract: Rac1 is a small member of Rho GTPase family. One of the most important downstream effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational activation of PAK1 by Rac1 has oncogenic signaling… read more here.
Keywords: rac1 pak1; pak1; gtp; intrinsic dynamics ... See more keywords