Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2056822
Abstract: ABSTRACT Circular RNA (circRNA) circ_0008717 has been revealed to promote cell carcinogenesis in non-small cell lung cancer (NSCLC). Exosomal circRNA packaged into exosomes has been defined as a potential diagnostic and therapeutic biomarker of cancers.… read more here.
Keywords: mir 1287; cell; circ 0008717; pak2 ... See more keywords
Role of activated p21-activated kinase 2 in methylmercury-induced embryotoxic effects on mouse blastocysts
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DOI: 10.1093/toxres/tfad030
Abstract: Methylmercury (MeHg), a biotransformation product derived from mercury or inorganic mercury compounds in waterways, is a potent toxin that exerts hazardous effects on human health via environmental contamination. Previous studies have reported MeHg-induced impairment of… read more here.
Keywords: development; methylmercury; kinase; pak2 ... See more keywords
Pak2 regulates myeloid-derived suppressor cell development in mice.
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DOI: 10.1182/bloodadvances.2017007435
Abstract: Myeloid-derived suppressor cells (MDSCs) are CD11b+Gr1+ cells that induce T-cell hyporesponsiveness, thus impairing antitumor immunity. We have previously reported that disruption of Pak2, a member of the p21-activated kinases (Paks), in hematopoietic stem/progenitor cells (HSPCs)… read more here.
Keywords: derived suppressor; mice; pak2; cell ... See more keywords
LncRNA RP11-499E18.1 Inhibits Proliferation, Migration, and Epithelial–Mesenchymal Transition Process of Ovarian Cancer Cells by Dissociating PAK2–SOX2 Interaction
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DOI: 10.3389/fcell.2021.697831
Abstract: Background: Ovarian cancer (OC)is a deadly gynecological malignancy worldwide. It is urgent to identify diagnostic biomarkers of OC to disclose the underlying mechanism. Methods and Materials: Bioinformatics analysis was used to identify target genes. Gene… read more here.
Keywords: proliferation migration; rp11 499e18; 499e18 pak2; pak2 sox2 ... See more keywords
MicroRNA-194-5p Attenuates Doxorubicin-Induced Cardiomyocyte Apoptosis and Endoplasmic Reticulum Stress by Targeting P21-Activated Kinase 2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.815916
Abstract: Objective Many studies have reported that microRNAs (miRs) are involved in the regulation of doxorubicin (DOX)-induced cardiotoxicity. MiR-194-5p has been reported significantly upregulated in patients with myocardial infarction; however, its role in myocardial diseases is… read more here.
Keywords: apoptosis; dox; dox induced; pak2 ... See more keywords