Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2016.98
Abstract: Although the pathogenesis of schizophrenia (SCZ) is proposed to involve alterations of neural circuits via synaptic dysfunction, the underlying molecular mechanisms remain poorly understood. Recent exome sequencing studies of SCZ have uncovered numerous single-nucleotide variants… read more here.
Keywords: pak3; git1; functional analysis; rare variants ... See more keywords
Circ_0000190 suppresses gastric cancer progression potentially via inhibiting miR-1252/PAK3 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01422-5
Abstract: Background Gastric cancer is a serious malignant tumor associated with aberrant circular RNAs (circRNAs) expression. In this study, we aim to investigate the role and the underlying mechanism of circ_0000190, a circRNA in gastric cancer.… read more here.
Keywords: pak3; gastric cancer; circ 0000190; mir 1252 ... See more keywords
PAK3 promotes the metastasis of hepatocellular carcinoma by regulating EMT process
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.61918
Abstract: Purpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. The malignant biological behavior of HCC is closely related to epithelial-mesenchymal transition (EMT), and EMT plays an important role in the progression, migration… read more here.
Keywords: hepatocellular carcinoma; hcc; expression; pak3 ... See more keywords