PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32384
Abstract: BACKGROUND & AIMS p21 activated kinase 4 (PAK4), an oncogenic protein, has emerged as a promising target for anti-cancer drug development. Its role in oxidative stress conditions, however, remains elusive. We investigated the effects of… read more here.
Keywords: pak4; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Combined anti-PD-L1 and anti-VEGFR2 therapy promotes the antitumor immune response in GBM by reprogramming tumor microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02427-7
Abstract: Inhibitors of programmed cell death ligand 1 (PD-L1) and vascular endothelial growth factor receptor 2 (VEGFR2) are commonly used in the clinic, but they are beneficial for only a minority of glioblastoma multiforme (GBM) patients.… read more here.
Keywords: anti vegfr2; vegfr2 therapy; therapy; tumor microenvironment ... See more keywords
PAK4 phosphorylates and inhibits AMPKα to control glucose uptake
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51240-w
Abstract: Our recent studies have identified p21-activated kinase 4 (PAK4) as a key regulator of lipid catabolism in the liver and adipose tissue, but its role in glucose homeostasis in skeletal muscle remains to be explored.… read more here.
Keywords: skeletal muscle; phosphorylates inhibits; pak4 phosphorylates; pak4 ... See more keywords
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2106478
Abstract: Abstract p21-Activated kinase 4 (PAK4), one of the serine/threonine kinases activated by Rho-family GTPases, has been widely studied as an oncogenic protein that is overexpressed in many types of cancers. In our recent study, PAK4… read more here.
Keywords: mice; activated kinase; p21 activated; pak4 ... See more keywords
P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac050
Abstract: Abstract Exploiting the pluripotent properties of embryonic stem cells (ESCs) holds great promise for regenerative medicine. Nevertheless, directing ESC differentiation into specialized cell lineages requires intricate control governed by both intrinsic and extrinsic factors along… read more here.
Keywords: cell; embryonic stem; kinase; pluripotency ... See more keywords
miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Asia-Pacific journal of clinical oncology"
DOI: 10.1111/ajco.13519
Abstract: AIM To explore the biological function of miR-425/PAK4 axis in proliferation, metastasis, and apoptosis of ovarian cancer (OC) cells. METHODS qRT-PCR and Western blot were adopted to examine miR-425 and PAK4 expressions in OC tissues… read more here.
Keywords: proliferation metastasis; mir 425; metastasis apoptosis; proliferation ... See more keywords
Abstract 2370: Depletion of p21-activated kinase 4, PAK4, inhibits cellular proliferation, motility and clonogenicity in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2370
Abstract: Oral squamous cell carcinoma (OSCC) accounts for 90% of all malignancies in the oral cavity, and is often associated with low survival and poor prognosis. While considerable progress in OSCC treatment has been made, options… read more here.
Keywords: oral squamous; squamous cell; proliferation; depletion ... See more keywords
Abstract 4368: PAK4-NAMPT dual inhibition as a feasible strategy for treatment of resistant pancreatic neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4368
Abstract: Our studies in pancreatic neuroendocrine tumor (pNET) cell lines demonstrate hyper-activation of the Rho GTPase effector p21 activated kinase 4 (PAK4) and the nicotinamide adenine dinucleotide (NAD) salvage pathway rate limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT).… read more here.
Keywords: pak4 nampt; pancreatic neuroendocrine; kpt; pak4 ... See more keywords
Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA.
Sign Up to like & getrecommendations! Published in 2021 at "Histology and histopathology"
DOI: 10.14670/hh-18-327
Abstract: BACKGROUND Oral squamous cell carcinoma (OSCC) is one of the most comment types of oral malignancies. SET-domain-containing protein 6 (SETD6) was recently identified as an important regulator of multiple signaling pathways through methylating protein substrates.… read more here.
Keywords: oral squamous; pak4; rela; methylation ... See more keywords
The significance of PAK4 in signaling and clinicopathology: A review
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0064
Abstract: Abstract P21-activated protein kinases (PAKs) are thought to be at the center of tumor signaling pathways. As a representative member of the group II PAK family, P21-activated protein kinase 4 (PAK4) plays an important role… read more here.
Keywords: signaling clinicopathology; review; pak4 signaling; significance ... See more keywords
CDC42 binds PAK4 via an extended GTPase-effector interface
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.2210/pdb5upk/pdb
Abstract: The p21-activated kinase (PAK) group of serine/threonine kinases are downstream effectors of RHO GTPases and play important roles in regulation of the actin cytoskeleton, cell growth, survival, polarity, and development. Here we probe the interaction… read more here.
Keywords: cdc42; kinase; binds pak4; pak4 via ... See more keywords