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Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32384
Abstract: BACKGROUND & AIMS p21 activated kinase 4 (PAK4), an oncogenic protein, has emerged as a promising target for anti-cancer drug development. Its role in oxidative stress conditions, however, remains elusive. We investigated the effects of…
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Keywords:
pak4;
ischemia reperfusion;
reperfusion injury;
injury ... See more keywords
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Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2106478
Abstract: Abstract p21-Activated kinase 4 (PAK4), one of the serine/threonine kinases activated by Rho-family GTPases, has been widely studied as an oncogenic protein that is overexpressed in many types of cancers. In our recent study, PAK4…
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Keywords:
mice;
activated kinase;
p21 activated;
pak4 ... See more keywords
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Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac050
Abstract: Abstract Exploiting the pluripotent properties of embryonic stem cells (ESCs) holds great promise for regenerative medicine. Nevertheless, directing ESC differentiation into specialized cell lineages requires intricate control governed by both intrinsic and extrinsic factors along…
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Keywords:
cell;
embryonic stem;
kinase;
pluripotency ... See more keywords
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Published in 2021 at "Asia-Pacific journal of clinical oncology"
DOI: 10.1111/ajco.13519
Abstract: AIM To explore the biological function of miR-425/PAK4 axis in proliferation, metastasis, and apoptosis of ovarian cancer (OC) cells. METHODS qRT-PCR and Western blot were adopted to examine miR-425 and PAK4 expressions in OC tissues…
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Keywords:
proliferation metastasis;
mir 425;
metastasis apoptosis;
proliferation ... See more keywords
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Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2370
Abstract: Oral squamous cell carcinoma (OSCC) accounts for 90% of all malignancies in the oral cavity, and is often associated with low survival and poor prognosis. While considerable progress in OSCC treatment has been made, options…
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Keywords:
oral squamous;
squamous cell;
proliferation;
depletion ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4368
Abstract: Our studies in pancreatic neuroendocrine tumor (pNET) cell lines demonstrate hyper-activation of the Rho GTPase effector p21 activated kinase 4 (PAK4) and the nicotinamide adenine dinucleotide (NAD) salvage pathway rate limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT).…
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Keywords:
pak4 nampt;
pancreatic neuroendocrine;
kpt;
pak4 ... See more keywords
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Published in 2021 at "Histology and histopathology"
DOI: 10.14670/hh-18-327
Abstract: BACKGROUND Oral squamous cell carcinoma (OSCC) is one of the most comment types of oral malignancies. SET-domain-containing protein 6 (SETD6) was recently identified as an important regulator of multiple signaling pathways through methylating protein substrates.…
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Keywords:
oral squamous;
pak4;
rela;
methylation ... See more keywords
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1
Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0064
Abstract: Abstract P21-activated protein kinases (PAKs) are thought to be at the center of tumor signaling pathways. As a representative member of the group II PAK family, P21-activated protein kinase 4 (PAK4) plays an important role…
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Keywords:
signaling clinicopathology;
review;
pak4 signaling;
significance ... See more keywords
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Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.2210/pdb5upk/pdb
Abstract: The p21-activated kinase (PAK) group of serine/threonine kinases are downstream effectors of RHO GTPases and play important roles in regulation of the actin cytoskeleton, cell growth, survival, polarity, and development. Here we probe the interaction…
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Keywords:
cdc42;
kinase;
binds pak4;
pak4 via ... See more keywords
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Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00271
Abstract: Japanese encephalitis virus (JEV) targets central nervous system, resulting in neuroinflammation with typical features of neuronal death along with hyper activation of glial cells. Exploring the mechanisms responsible for the JEV-caused inflammatory response remains a…
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Keywords:
encephalitis virus;
jev;
mediated inflammation;
japanese encephalitis ... See more keywords
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Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.956220
Abstract: The p21-activated kinase 4 (PAK4) is a member of the PAKs family. It is overexpressed in multiple tumor tissues. Pharmacological inhibition of PAK4 attenuates proliferation, migration, and invasion of cancer cells. Recent studies revealed that…
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Keywords:
development;
activated kinase;
pak4;
p21 activated ... See more keywords