Development of an organotypic stem cell model for the study of human embryonic palatal fusion.
Sign Up to like & getrecommendations! Published in 2018 at "Birth defects research"
DOI: 10.1002/bdr2.1394
Abstract: BACKGROUND Cleft palate (CP) is a common birth defect, occurring in an estimated 1 in 1,000 births worldwide. The secondary palate is formed by paired palatal shelves, consisting of a mesenchymal core with an outer… read more here.
Keywords: palatal; embryonic palatal; palatal fusion; fusion ... See more keywords
Correlation between HDAC4 enhancer DNA methylation and mRNA expression during palatal fusion induced by allâtrans retinoic acid
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27320
Abstract: Epithelialâmesenchymal transformation of the medial edge epithelium is the most crucial process in embryonic palatal fusion. This study aimed to explore the relationship and potential mechanism between enhancer DNA methylation and mRNA expression of histone… read more here.
Keywords: methylation; dna methylation; enhancer dna; palatal fusion ... See more keywords
Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.07.003
Abstract: Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog… read more here.
Keywords: palatal epithelium; signaling palatal; epithelium; hedgehog ... See more keywords
Genome-Wide DNA Methylation Analysis During Palatal Fusion Reveals the Potential Mechanism of Enhancer Methylation Regulating Epithelial Mesenchyme Transformation
Sign Up to like & getrecommendations! Published in 2018 at "DNA and Cell Biology"
DOI: 10.1089/dna.2018.4141
Abstract: Epithelial mesenchyme transformation (EMT) of the medial edge epithelium (MEE) is the crucial process during palatal fusion. This work is aimed to elucidate the enhancer regulatory mechanism by genome-wide DNA methylation analysis of EMT during… read more here.
Keywords: methylation; dna; analysis; palatal fusion ... See more keywords
Histological and Immunohistochemical Studies to Determine the Mechanism of Cleft Palate Induction after Palatal Fusion in Mice Exposed to TCDD
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042069
Abstract: Rupture of the basement membrane in fused palate tissue can cause the palate to separate after fusion in mice, leading to the development of cleft palate. Here, we further elucidate the mechanism of palatal separation… read more here.
Keywords: cleft palate; palate; mechanism; palatal fusion ... See more keywords