Spectrum and clinical relevance of PALB2 germline mutations in 7657 Chinese BRCA1/2-negative breast cancer patients
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DOI: 10.1007/s10549-019-05483-7
Abstract: To investigate the prevalence and clinical relevance of PALB2 germline mutations in BRCA1/2-negative breast cancer patients. The exons and intron–exon boundaries of the PALB2 gene were sequenced by multigene panel testing in a cohort of… read more here.
Keywords: negative breast; breast; palb2 germline; breast cancer ... See more keywords
Abstract 6086: PALB2 germline mutations in a large cohort Middle Eastern breast-ovarian cancer patients
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DOI: 10.1158/1538-7445.am2023-6086
Abstract: Background: The PALB2 gene encoding protein is involved in the homologous recombination repair pathway and plays an important role in maintaining genomic integrity. PALB2 heterozygous pathological variants (PV) or likely pathogenic variants (LPV) are associated… read more here.
Keywords: palb2 germline; breast ovarian; ovarian cancer; breast ... See more keywords