Paliperidone Palmitate 3-Monthly Versus 1-Monthly Injectable in Patients With Schizophrenia With or Without Prior Exposure to Oral Risperidone or Paliperidone: A Post Hoc, Subgroup Analysis
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DOI: 10.1007/s40261-018-0647-z
Abstract: Background and ObjectivePaliperidone palmitate 3-monthly (PP3M) injectable formulation offers an advantage of improved medication adherence and lower relapse risk in patients with schizophrenia. This post hoc analysis compared outcomes following PP3M versus paliperidone palmitate 1-monthly… read more here.
Keywords: ris pali; treatment; pali; exposure ... See more keywords
Effects on Satisfaction and Service Engagement of Paliperidone Palmitate Compared with Oral Paliperidone in Patients with Schizophrenia: An Open Label Randomized Controlled Trial
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DOI: 10.1007/s40261-018-0734-1
Abstract: Background and ObjectiveClinical practice guidelines recommend antipsychotic monotherapy, including oral and long-acting formulations, in the treatment of schizophrenia. This open-label, randomized, controlled trial aimed to evaluate the efficacy and tolerability in patients with schizophrenia of once-monthly… read more here.
Keywords: paliperidone; trial; satisfaction; service engagement ... See more keywords
Effect of lipid emulsion infusion on paliperidone pharmacokinetics in the acute overdose rat model: A potential emergency treatment for paliperidone intoxication
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DOI: 10.1016/j.ejps.2017.08.010
Abstract: &NA; Paliperidone prolongs cardiac repolarization in a concentration‐dependent manner. Meanwhile, continuous infusion of intravenous lipid emulsion (ILE) has been established as a detoxification therapy for lipophilic drugs. However, this change in pharmacokinetics of various drugs… read more here.
Keywords: plasma concentration; continuous infusion; infusion; lipid emulsion ... See more keywords
Paliperidone palmitate: Experience in a community mental health unit
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DOI: 10.1016/j.eurpsy.2017.01.1556
Abstract: Introduction There are many jobs that offer advantages of treatment with long-acting injectable in psychosis. Objective To know the changes in the different variables after the start of paliperidone palmitate (PP). Material and method We… read more here.
Keywords: experience community; paliperidone palmitate; community mental; paliperidone ... See more keywords
Can drug interaction be useful? Case report of a schizophrenic patient treated with paliperidone long-acting injection
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DOI: 10.1016/j.eurpsy.2017.01.1648
Abstract: Introduction Intramuscular paliperidone palmitate (PLAI) is a long-acting atypical anti-psychotic approved in Romania for the maintenance treatment of adults with schizophrenia. Objectives To determine the efficacy and tolerability of PLAI in a non-compliant patient with… read more here.
Keywords: plai; long acting; acting injection; paliperidone ... See more keywords
Switching to paliperidone palmitate in an outpatient sample: Preliminary results of a 43-month follow-up
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DOI: 10.1016/j.eurpsy.2017.02.375
Abstract: Introduction Patients with psychosis are treated in outpatient community clinics during most of their lifetime. Antipsychotic treatments are commonly used in regular clinical practice. However, the non-adherence is one of the main causes of relapses.… read more here.
Keywords: palmitate outpatient; paliperidone palmitate; switching paliperidone; paliperidone ... See more keywords
Aripiprazole: Examining the Clinical Implications of D2 Affinity
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DOI: 10.1017/s1092852923001232
Abstract: Abstract Background Aripiprazole has high binding affinity for the dopamine D2 receptor, which is thought to be responsible for the antipsychotic effect, though aripiprazole is not the most potent of the second-generation antipsychotics. Theoretically, aripiprazole… read more here.
Keywords: clinical implications; affinity; examining clinical; paliperidone ... See more keywords
A Review of Current Strategies in Treatment-Resistant Schizophrenia: Considering Paliperidone Palmitate LAI With and Without Olanzapine as an Alternative to Clozapine
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DOI: 10.1017/s109285292300202x
Abstract: Abstract Background Schizophrenia is a debilitating mental illness that affects patient’s function and quality of life. Estimates indicate a lifetime prevalence of 0.48%, causing up to 13.4 million years of life burdened by disability. 30%… read more here.
Keywords: effect; paliperidone palmitate; clozapine; paliperidone ... See more keywords
Microcrystals of Ketal-Linked Paliperidone Prodrugs for Long-Acting Antipsychotics.
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DOI: 10.1021/acs.molpharmaceut.2c00348
Abstract: Intramuscularly injectable long-acting prodrug-based microcrystals (MCs) are of particular interest for chronic disease management. Nevertheless, current prevalently used linkers degraded by enzymes have the potential drawback of substantial differences in enzyme levels between individuals. Here,… read more here.
Keywords: acting antipsychotics; ketal linked; prodrug; release ... See more keywords
Paliperidone LAI and Aripiprazole LAI Plasma Level Monitoring in the Prophylaxis of Bipolar Disorder Type I with Manic Predominance.
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DOI: 10.1055/a-1113-7862
Abstract: INTRODUCTION The objective of this study was the evaluation of utility of plasma level monitoring in the clinical stabilizing efficacy and tolerability of paliperidone palmitate (PP) vs. aripiprazole monohydrate (AM) in bipolar disorder I (BD… read more here.
Keywords: manic predominance; level monitoring; monitoring; plasma level ... See more keywords
Effects of body weight, smoking status, and sex on plasma concentrations of once-monthly paliperidone palmitate
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DOI: 10.1080/17512433.2022.2020641
Abstract: ABSTRACT Objectives Knowledge about the impact of body composition features on pharmacokinetics of newer long-acting injectable antipsychotics is limited. Methods We analyzed steady-state plasma concentrations of paliperidone in different body mass index (BMI), age, sex,… read more here.
Keywords: body; pp1m; paliperidone; plasma ... See more keywords